[Teratogenic effect of the fungicide calixin].

Experimental studies on Wistar rats revealed that the fungicide calixin (N-tridecyl-2.6-dimethylmorpholine) has a teratogenic effect. This effect manifested in edemas, hemorrhages, hematomas, abnormal development of the brain (hydrocephalia), visceral cranium (micrognathia, cleft palate) and genitourinary system (hydronephrosis), in decreased size of pelvic bones, shoulder girdle, front and hind limbs, etc.

[State of rat embryogenesis and progeny during exposure to foreign substances contained in the food].

Examination of the action of different xenobiotics (pesticides, heavy metals) on embryogenesis and progeny allowed the methodological approaches to this line of research to be suggested. It is recommended that xenobiotics be administered in different periods of embryogenesis: from day 1 to day 7, from day 7 to day 15 and from day 1 to day 20. It has been established that at cross mating the most pronounced alterations arose in the progeny of experimental males.

[Incorporation of thymidine-H3 into the DNP of rat tissues following a single injection of DNA].

The injection of a homologous DNA to rats caused an increased incorporation of H3-thymidine into DNP of the bone marrow, the spleen, the thymus, and the intestinal mucosa 24 hours after the administration. This effect was not revealed on the 3d day.

[Inhibiting effect of sodium dodecylsulphate on DNase of animal tissues].

The activity of DNases in homogenates of the spleen, thyroid gland and intestine mucosa of rats as well as in solution of purified pancreatic DNase was studied as affected by sodium dodecylsulphate. Dodecylsulphate has an inhibitory effect on all the studied DNase. The effect grows up to complete inhibition of DNases with an increase in the content of detergent in the incubation mixture from 0.