Publications by authors named "Ryou Okamoto"
Article Synopsis
- The article addresses the need to correct previously published errors related to document identifier DOI: 10.23922/jarc.2022-060.
- It highlights the importance of maintaining accurate and reliable information in academic research.
- The corrections aim to enhance the clarity and validity of the findings presented in the original article.
Article Synopsis
- Preoperative chemoradiotherapy (CRT) and total mesorectal excision improve local control for locally advanced rectal cancer (LARC), but do not significantly enhance survival due to distant metastasis being the main issue.
- Total neoadjuvant chemotherapy (TNT) is a newer strategy aimed at enhancing treatment effectiveness, showing better outcomes in several studies compared to standard CRT.
- Recent trials like PAPIDO and PRODIGE 23 have significantly demonstrated that TNT improves disease-free survival in LARC patients, highlighting promising advancements in cancer treatment approaches.
In this study, we developed novel siRNA transfer method to the liver by sequential intravenous injection of anionic polymer and cationic liposome/cholesterol-modified siRNA complex (cationic lipoplex). When cationic lipoplex was intravenously injected into mice, the accumulation of siRNA was mainly observed in the lungs. In contrast, when cationic lipoplex was intravenously injected at 1 min after intravenous injection of poly-L-glutamic acid (PGA) or chondroitin sulfate C (CS), siRNA was accumulated in the liver.
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