Publications by authors named "Ryota Takaoka"

Patients: This case report describes a procedure for assessing changes in occlusal relationships in patients with acquired open bites due to temporomandibular joint disease using an intraoral scanner (IOS). A digital impression was made using the IOS at the initial visit. Subsequent impressions were made every 6 months using the IOS and magnetic resonance imaging (MRI) or computed tomography (CT).

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  • * The study involved 40 OSCC patients, using real-time PCR to measure miRNA levels and conducting statistical analyses to understand their correlation with metastasis.
  • * Key findings indicated that miR-423 and miR-125 were effective in diagnosing primary neck lymph node metastases, while miR-5100 was useful for predicting late metastasis, suggesting potential for personalized treatment approaches.
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  • * The findings showed that ethnic differences in drug clearance were generally small, although variability did depend on the drug's clearance mechanism, with interindividual variability (IIV) matching well across ethnicities.
  • * The study emphasizes the importance of designing phase I clinical trials that consider the clearance mechanism to accurately assess ethnic differences and suggests that classification of drugs based on these mechanisms can aid in drug development.
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Purpose: This observational study aimed to elucidate the pathophysiology of subchondral cysts (SC) in the temporomandibular joint (TMJ) and examine the results of conservative therapy administered to patients with SCs in the TMJ.

Methods: The study included 41 patients with SCs, extracted from 684 consecutive patients who underwent magnetic resonance imaging (MRI). The anatomical features of SCs and positional abnormalities of the articular disc were initially evaluated using MRI.

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Temporal summation of second pain (TSSP) has been suggested as a psychophysical index for central sensitization, one of the critical mechanisms in the chronification of pain. However, there is no gold standard for protocols to measure TSSP. The purpose was to establish the stimulus intensity for measuring TSSP.

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Objective: This case report describes the orthodontic and prosthetic rehabilitation of a patient with resorption of the roots of the maxillary central incisors due to the ectopic maxillary canines.

Clinical Considerations: A 16-year-old woman presented with severe resorption of the roots of the maxillary central incisors due to the ectopic maxillary canines. The impacted canines were orthodontically tracted with a lingual arch-supporting temporary central incisors and vertical elastics, and, undesirable root proximity was later corrected by moving the canines distally 1.

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Objectives: The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity. The purpose of this study was to determine the effects of FTO polymorphism rs8044769 alleles on OA in the temporomandibular joint (TMJ), which is minimally affected by body weight.

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  • A model-based meta-analysis (MBMA) was conducted to evaluate how different medications for chronic heart failure (CHF) affect circulatory physiology, focusing on changes in heart rate, blood pressure, and ventricular volumes.
  • The study analyzed clinical data from 61 trials primarily involving patients with heart failure with reduced ejection fraction (HFrEF) and investigated medications like carvedilol and enalapril.
  • Key findings indicate that estimated myocardial oxygen consumption strongly correlated with mortality rates, supporting the idea that effective CHF treatment reduces cardiac load and enhances patient outcomes.
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Establishing continuous and symmetric gingival levels is essential to achieving optimal gingival esthetics. Adjustment of the subgingival contour of the interim prosthesis is useful for managing gingival levels. This article illustrates how to accurately and predictably transfer the adjusted subgingival contour of interim restorations to the definitive restorations by using zirconia copings customized with casting wax.

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Dynamic articular disc abnormality (wR, with reduction; woR, without reduction) is well known as the risk factor for temporomandibular joint osteoarthritis (TMJOA). However, there are few speculations on the potential risk of positional disc abnormalities for TMJOA. The purpose of this study was to investigate the relative risk of positional abnormality and dynamic abnormality of the temporomandibular disc for OA after the three-dimensional interpretation of all the sagittal and coronal planes of magnetic resonance (MR) data in a large dataset of consecutive subjects.

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