Stereochemical properties of quazepam and its affinity for the GABA receptor.

C9-methylated quazepam 1 was prepared, and its physicochemical properties were investigated. The atropisomers of 1 were isolated as (aR, aS) and (aS, aR) isomers. Their absolute configurations were determined based on ECD spectra in comparison with those calculated using the time-dependent density functional theory.

A closer look at the time course of bodily responses to awe experiences.

The structure and function of awe have been examined by focusing on the average level of outcomes during awe experiences. In the present study, we tested the psychophysiological process of experiencing awe, focusing on time-series changes in skin conductance responses (SCRs), a moment-by-moment measure of sympathetic nervous responses, and pupil diameter, which is dilated or constricted through the sympathetic and parasympathetic nervous system. The responses were measured through an experiment where 77 Japanese university students watched emotional (awe, amusement, or neutral) videos while moving a joystick when they felt supernatural agency or non-agency, examining the underlying psychological processes.

Development of a Japanese version of the Awe Experience Scale (AWE-S): A structural topic modeling approach.

Background: Awe, a complex emotion, arises in response to perceptually and conceptually vast stimuli that transcend one's current frames of reference, which is associated with subjective psychological phenomena, such as a sense of self and consciousness. This study aimed to develop a Japanese version of the Awe Experience Scale (AWE-S), a widely used questionnaire that robustly measured the state of awe, and simultaneously investigated how the multiple facets of awe related to the narrative representations of awe experiences.

Methods: The Japanese AWE-S was created via back-translation and its factor structure and validity was investigated through an online survey in Japan.

Relationships Between Meaning in Life and Positive and Negative Spirituality in a Field Setting in Japan.

This study examined the relationships between positive/negative spirituality and meaning in life at two religious sites in Japan. Participants reported greater sadness and less meaning in life at Koyasan Okunoin, a temple with graves surrounded by nature, than at Nachi Kumano Taisha, a shrine with a waterfall. However, greater feelings of happiness protected meaning in life in the presence of sadness at Koyasan.

Strengthened social ties in disasters: Threat-awe encourages interdependent worldviews via powerlessness.

Threat-awe, a negatively valenced variant of awe, is thought to strengthen social ties among community members. However, few empirical studies have examined the social functions of threat-awe. This study investigated whether threat-awe is linked to interdependent worldviews through feelings of powerlessness in comparison with positive awe.

Awe liberates the feeling that "my body is mine".

Awe is an emotional response to perceptually vast stimuli that transcend one's current frames of reference. Previous research indicated that awe promotes a smaller self, which led to the creation of a small-self hypothesis. Thus, we shed new light on this hypothesis in terms of sense of body ownership using a rubber hand illusion experiment; through it, we showed that awe evokes an increased sense of body ownership over the rubber hand and this effect was prominent among participants who experienced small self.

Neural representations of awe: Distinguishing common and distinct neural mechanisms.

Awe is an emotional response to perceptually vast stimuli that transcend one's current frames of reference. The psychological form and function of awe differ between two types: positive-awe, which arises from perceptually aesthetic experiences (e.g.