Publications by authors named "Ryota Koto"
Article Synopsis
- The study investigates the corneal characteristics of Japanese patients with myotonic dystrophy type 1 (DM1), focusing on those diagnosed with clinical neuromuscular symptoms and specific genetic markers.
- Researchers compared the corneal health of 10 DM1 patients to 37 healthy participants using advanced eye examination techniques.
- Findings indicate that DM1 patients exhibited mild corneal issues similar to Fuchs endothelial corneal dystrophy, with a significantly higher average endothelial cell density compared to the control group.
Article Synopsis
- The study aimed to explore the relationship between cytosine-thymine-guanine trinucleotide repeat (TNR) expansion in TCF4 and clinical features like corneal densitometry in patients with Fuchs endothelial corneal dystrophy.
- A total of 150 eyes from 75 Japanese patients were analyzed using advanced genetic techniques and imaging methods to assess their corneal characteristics.
- The results showed no significant differences in clinical traits between patients with significant TNR expansion and those without, including metrics like corneal thickness and morphology.
Am J Pathol
December 2020
Article Synopsis
- Gelatinous drop-like corneal dystrophy (GDLD) is a serious inherited eye condition caused by the accumulation of amyloid in the cornea, leading to vision problems.
- Researchers identified the TACSTD2 gene as the cause of GDLD, and studies in knockout mice showed similar symptoms, including a compromised epithelial barrier and corneal opacity.
- They developed a simple method to assess corneal barrier loss early on and successfully used the mouse model to explore GDLD's pathology and potential treatments.
