Publications by authors named "Ryota Hosoda"
Biochem Biophys Rep
September 2024
Article Synopsis
- Aging increases the risk of obstructive and fibrotic lung diseases, which are marked by lung function decline due to tissue scarring and excess collagen deposition, primarily mediated by TGF-β signaling.
- Decorin (DCN) is a key protein that can block TGF-β signaling, and while traditionally seen as an irreversible condition, pulmonary fibrosis might be treatable with interventions.
- This study found that chicken eggshell membrane (ESM) significantly boosts DCN secretion in lung fibroblasts, especially when combined with proteins like lysozyme and ovotransferrin, suggesting potential therapeutic pathways for managing pulmonary fibrosis.
