Publications by authors named "Ryosuke Yasuda"
Article Synopsis
- This study investigates benign recurrent intrahepatic cholestasis (BRIC) in seven Japanese patients, focusing on clinicopathologic features, genetics, treatment, and outcomes.
- The patients included in the study were diagnosed with either BRIC type 1 or type 2, with varying ages of onset and intermittent cholestatic attacks over an 11-year follow-up period.
- Treatment with rifampicin and cholestyramine was effective in managing symptoms, and none of the patients developed cirrhosis, indicating overall satisfactory long-term outcomes.
Article Synopsis
- The study investigated serum levels of leucine-rich alpha-2 glycoprotein (LRG) and calprotectin as markers for disease activity in children with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
- A total of 173 pediatric patients were analyzed, revealing that LRG levels were significantly higher in active cases of CD compared to remission and normal controls, while calprotectin showed similar trends but was less consistently different in UC.
- The findings suggest that serum LRG is a potentially more reliable marker of disease activity in pediatric IBD, especially for CD, compared to traditional markers like calprotectin.
Background: Part 1 of the DORA study, a 2019 international clinical trial of glecaprevir and pibrentasvir (G/P) treatment in adolescents with chronic hepatitis C virus (HCV) infection, demonstrated high efficacy and safety. However, few reports have considered real-world experience with G/P treatment in adolescents with chronic HCV. The present prospective multicenter study assessed real-world efficacy and safety of G/P treatment in Japanese adolescents with chronic HCV.
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- The study analyzed the role and methods of diagnostic colonoscopy in pediatric patients over two distinct time periods at Kurume University Hospital, comparing data from 2007-2015 to 2015-2022.
- A total of 274 patients were included, revealing a shift in primary indications for colonoscopy from hematochezia to abdominal pain, along with a rise in cases of Crohn's disease and eosinophilic gastrointestinal disorder.
- The study noted improvements in bowel preparation and sedation techniques, emphasizing the growing importance of colonoscopy for diagnosing inflammatory bowel diseases in children.
Immunoglobulin A vasculitis (IgAV) is a systemic small-vessel vasculitis. Although corticosteroids (CS) are the primary treatment for gastrointestinal manifestations associated with IgAV, some patients develop refractory or recurrent symptoms such as vomiting and abdominal pain despite CS treatment. Dapsone, a synthetic sulfone antimicrobial, has been used to treat cutaneous purpura in IgAV, but few authors have reported its use for refractory gastrointestinal symptoms.
View Article and Find Full Text PDFBackground: Biliary atresia (BA) is among the commonest indications for liver transplantation (LT) in children. We examined whether serum matrix metalloproteinase-7 (MMP-7) is useful for diagnosis of BA in Japanese infants, and whether serum MMP-7 concentrations before and after Kasai portoenterostomy (KP) predicted LT within a year.
Methods: Subjects under 6 months old at eight pediatric centers in Japan were enrolled retrospectively, including patients with cholestasis and normal controls (NC) without liver disease.
Background: Reports of zinc and selenium deficiencies accompanying inflammatory bowel disease (IBD) mostly have originated from Western countries and concerned adult patients. Whether Japanese children with IBD have similar deficiencies remained unclear.
Aim: We aimed to elucidate differences in serum zinc and selenium concentrations in Japanese children between types of IBD.
Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children. Subjects under 6 months old at 7 pediatric centers in Japan were prospectively enrolled, including patients with cholestasis and healthy controls (HC) without liver disease.
View Article and Find Full Text PDFBackground And Aim: Few studies of zinc monotherapy for presymptomatic Wilson disease have focused on young children. We therefore evaluated long-term efficacy and safety of zinc monotherapy for such children and established benchmarks for maintenance therapy.
Methods: We retrospectively and prospectively examined children under 10 years old with presymptomatic Wilson disease who received zinc monotherapy from time of diagnosis at 12 participating pediatric centers in Japan.
The rheological behavior of galactomannans in concentrated solutions was examined by using dynamic viscoelasticity measurements. Concentrated solutions of three galactomannans, guar gum, tara gum, and locust bean gum were prepared with an ionic liquid 1-butyl-3-methylimidazolium chloride as the solvent. Each galactomannan solution showed angular frequency dependence curves of the storage modulus and the loss modulus which were characteristic of a solution of entangled polymer chains.
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