Publications by authors named "Ryosuke Shibata"

A 74-year-old man was diagnosed with squamous cell carcinoma of the lower thoracic esophagus following an upper gastrointestinal endoscopy during a health check-up, which revealed a type 0-IIc tumor. Biopsy confirmed squamous cell carcinoma, with suspicion of submucosal invasion. The patient was referred to our department.

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Background/aim: Self-expandable metallic stent (SEMS) placement is becoming the standard bridge-to-surgery (BTS) strategy for potentially curable left-sided obstructive colorectal cancer (OCRC). The study objective was to evaluate the effectiveness of SEMS placement as a BTS strategy for both right- and left-sided OCRC.

Patients And Methods: We retrospectively compared the short- and long-term outcomes of patients with OCRC who underwent placement of a SEMS versus a trans-nasal/anal decompression tube (DCT).

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Purpose: The current study summarized the clinical course and treatment outcomes of intestinal cancer in CD seen in our department and explored the steps to take in the future.

Methods: Subjects were patients who had been diagnosed with CD at our hospital and who underwent surgery in our department from 1985 to 2020.

Results: Thirty-one patients had CD and intestinal cancer, including 6 with cancer of the small intestine and 25 with cancer of the large intestine.

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Article Synopsis
  • A 77-year-old woman developed a dilated main pancreatic duct after gastric cancer surgery, which led to the discovery of a low-grade tumor called an intraductal papillary mucinous neoplasm.
  • To treat this condition while preserving her stomach, she underwent a laparoscopic distal pancreatectomy that preserved blood flow to her remaining stomach due to careful surgical techniques.
  • The surgery was successful with minimal blood loss, and her recovery was smooth, highlighting the effectiveness of this approach for patients with similar medical histories.
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An 83-year-old woman underwent laparoscopic distal gastrectomy and Billroth Ⅱ reconstruction for gastric cancer. Since histopathological examination revealed that the lesion was Stage ⅢA, she had started taking S-1 as an adjuvant chemotherapy 7 weeks after gastrectomy. Seventeen days later after taking S-1 administration, she felt nauseous and self-interrupted.

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Rapid postprandial blood glucose elevation can cause lifestyle-related diseases, such as type II diabetes. The absorption of food-derived glucose is primarily mediated by sodium/glucose cotransporter 1 (SGLT1). Moderate SGLT1 inhibition can help attenuate postprandial blood glucose elevation and prevent lifestyle-related diseases.

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  • Primary gastric synovial sarcoma is extremely rare, with only 44 documented cases, and this study highlights a first-ever laparoscopic endoscopic cooperative surgery for this condition.
  • A 45-year-old male patient was diagnosed with a gastric tumor that was ultimately identified as synovial sarcoma through various diagnostic techniques, including esophagogastroduodenoscopy and imaging.
  • The successful surgical removal of the tumor using a novel approach called laparoscopic endoscopic cooperative surgery (LECS) demonstrated its effectiveness for treating small, difficult-to-confirm tumors without compromising the gastric wall.
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Introduction And Importance: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is often found incidentally during examination for other diseases. In addition to the risk of malignant transformation, patients with IPMN are at risk of developing pancreatic cancer. We report a case of pancreatic tail cancer that developed separately from a preexisting IPMN after minimally invasive esophagectomy for cancer of the esophagogastric junction and was resected successfully by laparoscopic distal pancreatectomy.

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A 69-year-old man, who had undergone distal gastrectomy for duodenal ulcer, was diagnosed with remnant gastric cancer and jejunal mesenteric lymph node metastasis. To improve curability, we planned 2 courses of S-1 and cisplatin therapy. After chemotherapy, primary lesion and lymph node metastases reduced in size drastically.

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We report a case of locally far-advanced colon cancer resected by laparoscopic surgery after colonic stent insertion and neoadjuvant chemotherapy. A 71-year-old man with obstructive symptoms was admitted to our hospital in July 2015. CT revealed a sigmoid colon tumor infiltrating the retroperitoneum and small intestine.

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Article Synopsis
  • - The study aimed to see if an intensive preoperative respiratory rehabilitation (PR) program could prevent pulmonary complications after esophagectomy in esophageal cancer patients.
  • - It involved 60 patients, with one group undergoing rehabilitation for over a week and the other group not receiving any prior rehab.
  • - Results showed significantly lower complications in the PR group, indicating that preoperative rehabilitation can effectively reduce risk factors for postoperative issues.
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  • The Geriatric Nutritional Risk Index (GNRI) is a new tool designed to evaluate the nutritional status and predict complications in elderly patients, but its efficacy in gastrointestinal cancer patients has not been well-studied.
  • In a study of 122 esophageal cancer patients who underwent surgery, researchers compared outcomes based on GNRI scores, categorizing patients into high (≥90) and low (<90) risk groups.
  • Findings revealed that the low GNRI group faced significantly higher rates of respiratory complications, establishing GNRI as a valuable marker for predicting postoperative risks in this patient population.*
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Article Synopsis
  • * She received neoadjuvant chemotherapy (TS-1 combined with CDDP) which helped reduce the tumor size and improve her serum protein levels ahead of surgery.
  • * Following chemotherapy, she successfully underwent a total gastrectomy and additional procedures, highlighting the potential effectiveness of neoadjuvant treatment for such patients.
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  • Gastric stump carcinoma, first identified in 1922, has been extensively studied, focusing on its epidemiology, causes, and characteristics, particularly in relation to infections such as H. pylori and Epstein-Barr virus.* -
  • Research indicates that there is no significant difference in prognosis between gastric stump carcinoma and primary gastric cancer located in the upper third of the stomach.* -
  • Recent advances, such as endoscopic submucosal dissection, are being used for early-stage treatment of gastric stump carcinoma, although many aspects, especially regarding molecular biology and H. pylori's role in its development, still need further investigation.*
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Article Synopsis
  • The study aimed to evaluate the effectiveness of the high-sensitivity Glasgow prognostic score (HS-GPS) after surgery in gastric cancer patients and to identify factors influencing score improvement.
  • In a retrospective analysis of 236 gastric cancer patients, researchers found that changes in HS-GPS from before to after surgery correlated with patient outcomes and prognostic factors.
  • The results indicated that HS-GPS after surgery is a significant independent predictor of prognosis, suggesting that patients with no score improvement may need additional treatments like adjuvant chemotherapy.
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Human epidermal growth factor receptor 2 (HER2) status has been evaluated at the primary site of gastric cancer when planning trastuzumab therapy against recurrent or metastatic lesions, since tissue sampling is uncommon in recurrent or metastatic lesions. This study retrospectively investigated the concordance of HER2 expression between primary and metastatic/recurrent lesions in order to confirm sensitivity to trastuzumab. The subjects comprised 37 patients with gastric adenocarcinoma who underwent tissue biopsy or surgical resection of the primary sites and 49 paired synchronous or metachronous metastatic sites (excluding lymph nodes) at the Fukuoka University Hospital between January, 1998 and September, 2012.

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Article Synopsis
  • The study aimed to assess how effective the high-sensitivity modified Glasgow prognostic score (HS-mGPS) is at predicting outcomes for gastric cancer patients before they undergo surgery.
  • Involving 552 patients, the study found that both the HS-mGPS and the traditional mGPS were strong predictors of prognosis, with HS-mGPS showing a particular advantage in identifying risk for patients with stage I and IV gastric cancer.
  • The findings suggest that using HS-mGPS provides better prognostic information compared to the standard mGPS in surgical candidates with gastric cancer.
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