Prolonged viral shedding of SARS-CoV-2 in an immunocompromised patient.

The duration of viral shedding of SARS-CoV-2 is usually less than 10 days. We experienced a COVID-19 case with prolonged viral shedding for 2 months. His cell mediated immunity has been depressed (CD4T cell <100/μl) due to advanced malignant lymphoma and chemotherapy which had been completed 4 months prior to the onset of symptoms of COVID-19.

Eco-Friendly Push-Coated Polymer Solar Cells with No Active Material Wastes Yield Power Conversion Efficiencies over 5.5.

Push-coating is a simple process that can be employed for extremely low-cost polymer electronic device production. Here, we demonstrate its application to the fabrication of poly(2,7-carbazole- alt-dithienylbenzothiadiazole) (PCDTBT):[6,6]-phenyl-C-butyric acid methyl ester (PCBM) active layers processed in air, yielding similar photovoltaic performances as thermally annealed spin-coated thin films when used in inverted polymer solar cells (PSCs). During push-coating, the polydimethylsiloxane layer temporarily traps the deposition solvent, resulting in simultaneous film formation and solvent annealing effect.

Projection of invertebrate populations in the headwater streams of a temperate catchment under a changing climate.

Climate change places considerable stress on riverine ecosystems by altering flow regimes and increasing water temperature. This study evaluated how water temperature increases under climate change scenarios will affect stream invertebrates in pristine headwater streams. The studied headwater-stream sites were distributed within a temperate catchment of Japan and had similar hydraulic-geographical conditions, but were subject to varying temperature conditions due to altitudinal differences (100 to 850 m).

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.

We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and growth suppression of cancer cells. High-throughput screening and medicinal chemistry efforts led to the identification of structurally diverse SPT inhibitors 4 and 5. Both compounds potently inhibited SPT enzyme and decreased intracellular ceramide content.

Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1)-one Derivatives as Orally eIF4A3-Selective Inhibitors.

Starting from our previous eIF4A3-selective inhibitor , a novel series of (piperazine-1-carbonyl)pyridin-2(1)-one derivatives was designed, synthesized, and evaluated for identification of orally bioavailable probe molecules. Compounds and showed improved physicochemical and ADMET profiles, while maintaining potent and subtype-selective eIF4A3 inhibitory potency. In accord with their promising PK profiles and results from initial in vivo PD studies, compounds and showed antitumor efficacy with T/C values of 54% and 29%, respectively, without severe body weight loss.

Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid.

We describe a methodology for quick development of fluorescent probes with the desired potency for the target of interest by using a method of parallel synthesis, termed as Parallel Fluorescent Probe Synthesis (Parallel-FPS). BODIPY FL propionic acid 1 is a widely used fluorophore, but it is difficult to prepare a large amount of 1, which hinders its use in parallel synthesis. Optimization of a synthetic scheme enabled us to obtain 50g of 1 in one batch.