Publications by authors named "Ryoma Kato"
Article Synopsis
- Invariant natural killer T (iNKT) cells are a unique type of T lymphocyte characterized by semi-invariant T cell receptors that recognize lipid antigens, playing a key role in both innate and adaptive immune responses against infections and tumors.
- This review examines the development and function of iNKT cells, focusing on transcription factors, effector molecules, and how their characteristics vary based on location in tissues like the thymus, lung, and liver.
- The article also discusses how cytokine production affects iNKT cell diversity in different immune environments and considers the potential for using this diversity to develop effective immunotherapies for cancer.
CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s.
Proc Natl Acad Sci U S A
September 2023
Article Synopsis
- Group 2 innate lymphoid cells (ILC2s) play a key role in combating parasites and maintaining tissue health, but factors limiting their function are not well understood.
- Research indicates that CD45, a protein important for T cell development, negatively regulates the proliferation and activity of ILC2s in a way that impacts their function.
- The study also shows that CD45 helps control type 2 inflammation in the lungs by interacting with ILC2s, suggesting it may be a potential target for treating lung inflammation and fibrosis.