Publications by authors named "Ryoko Kikuchi-Koike"
Article Synopsis
- The ubiquitin-proteasome pathway is crucial for regulating cellular proteins, and recent studies are identifying deubiquitinating enzymes (DUBs) as new targets for cancer therapies, especially in breast, endometrial, and prostate cancers, as well as multiple myeloma.
- Research shows that the DUB inhibitor bAP15 can inhibit cell growth in various cancers; however, its mechanism in ovarian cancer is still not fully understood.
- In a study involving 1,435 ovarian cancer patients, high UCHL5 expression was linked to shorter progression-free survival, and bAP15 was found to induce cancer cell death by affecting TGF-β signaling, suggesting UCHL5 inhibition could be a promising
Background: Patients with lymph node metastasis-negative (pN0) invasive breast cancer have favorable outcomes following initial treatment. However, false negatives which occur during routine histologic examination of lymph nodes are reported to underestimate the clinical stage of disease. To identify a high-risk group in pN0 invasive breast cancer, we examined copy number alterations (CNAs) of 800 cancer-related genes.
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