[A case of hepatocellular carcinoma resolved by hepatic resection for local treatment].

A 76-year-old man with chronic hepatitis B was found to have a liver mass during a treatment of hypertension and atrial fibrillation at his local clinic, and was hospitalized to our hospital. Laboratory results on admission showed a mild hepatic impairment (grade B) and tumor markers AFP 12 ng/mL and PIVKA-II 10,169 mAU/mL. Hepatic ultrasonography revealed a hypoechoic mass measuring 8-cm in diameter in the medial segment of the liver, and portography showed an extension of the right branch of the portal vein with no obvious tumor embolism.

Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in an immunocompetent animal model.

The prognosis of pancreatic cancer with peritoneal dissemination has not improved. The aim of this study was to clarify whether oncolytic reovirus is effective against the peritoneal dissemination of pancreatic cancer in an immunocompetent animal model. The hamster pancreatic cancer cells HaP-T1 were inoculated into the peritoneal cavity of the hamster and reovirus (1x10(8) plaque-forming units) was administered into the peritoneal cavity on days 1, 3, 5 and 7 after HaP-T1 inoculations.

Adenomyomatous hyperplasia of the common bile duct: report of a case.

Adenomyomatous hyperplasia is most commonly found in the stomach, gallbladder, duodenum, and jejunum, while it is rarely found in the extrahepatic bile duct. A 62-year-old woman was referred to our institution with a diagnosis of common bile duct (CBD) stenosis which had been detected by endoscopic retrograde cholangiopancreatography (ERCP). Abdominal computed tomography with contrast medium revealed a thickening of the wall of the lower CBD, and this lesion was weakly enhanced by contrast medium in the arterial phase.

A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model.

Proteinase-activated receptor-2 (PAR-2), which is a G protein-coupled receptor, is activated in inflammatory processes and cell proliferation. We previously demonstrated that an anti-PAR-2 antibody suppresses proliferation of human pancreatic cells in vitro. However, there have been no studies of PAR-2 signaling pathways in vivo.

Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection.

Prognostic values of leukocyte subset counts in peripheral blood of cancer patients have not yet been fully investigated. We retrospectively examined the relation between preoperative absolute counts of peripheral blood leukocyte subsets and clinicopathologic factors and long-term prognosis in 97 patients with liver metastasis from colorectal cancer who underwent hepatic resection. Median preoperative peripheral blood leukocyte subset counts were as follows: neutrophils 3148/mm3; lymphocytes 1574/mm3; monocytes 380/mm3.