Wide-bore capillary hydrodynamic chromatography with ICP-MS detection for evaluation of lanthanide uptake by molecular aggregates.

Wide-bore capillary hydrodynamic chromatography (W-HDC) resolves analytes on the basis of a difference in the extent of radial diffusion simply by their passage through an empty capillary. The combination of this method with ICP-MS proves efficient for the evaluation of the interaction of metal ions with molecular aggregates. Lecithin vesicles are suitable molecular aggregates for the uptake of the lanthanide ions in the presence of the first row transition metal ions, suggesting that the present method is applicable to the screening of the molecular aggregate system suitable for selective extraction of a particular targeted small molecule.

Wide-bore hydrodynamic chromatography in sub-second range.

Wide-bore hydrodynamic chromatography (HDC) is a very simple method based on the passage of analytes through an open capillary. As shown in previous papers, an analyte, which diffuses over the entire cross-section of a capillary before it is detected, gives a Gaussian-shaped peak; such an analyte is called diffusive. In contrast, an analyte with poor diffusivity gives an asymmetrical peak with the apex at the half time of the peak of a diffusive analyte.