Publications by authors named "Ryoji Igi"
Article Synopsis
- Previous research showed that L-octaarginine linked to hyaluronic acid can improve the absorption of protein drugs under 22 kDa when taken intranasally.
- This study explored its use for larger antibody drugs, showing that the bioavailability of ranibizumab (48 kDa) increased from 0.67% to 6.2% when combined with the hyaluronic acid derivative.
- Results indicated that this absorption enhancement mechanism relies on syndecan-4-induced macropinocytosis, making it effective for various antibody sizes, with no involvement from clathrin or caveolin-1 in the uptake process.
Our previous mouse studies demonstrated that mean bioavailability of exendin-4, which is an injectable glucagon-like peptide-1 (GLP-1) analogue whose molecular weight (Mw) and isoelectric point (pI) are ca. 4.2 kDa and 4.
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