Publications by authors named "Ryoichi Miyamoto"

Article Synopsis
  • In colorectal cancer, the type of fibrotic stroma in tumors helps predict patient outcomes, while in pancreatic cancer (PC), the fibrotic stroma, called desmoplasia, needs better characterization for prognostic evaluation.
  • A study of 167 patients with resected PC classified desmoplastic reactions into mature, intermediate, and immature patterns and analyzed their impact on survival rates.
  • Results indicated that mature desmoplastic patterns are linked to better disease-free survival, suggesting that understanding these patterns could improve treatment strategies for PC patients.
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Background: Tumor-associated sarcoid reactions have been observed with various tumors; however, they have not been reported with uterine cancer. We present two cases of splenic sarcoid reactions that mimicked metastases a few years after uterine cancer surgery.

Case Presentation: Case 1 involved a 67-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1).

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Objectives: Postoperative pancreatic fistula (POPF) is a major cause of morbidity after pancreatic surgery. Recently, endoscopic ultrasound-guided transmural drainage (EUS-TD) has been widely used to manage pancreatic pseudocysts after acute pancreatitis. Several studies have reported the effectiveness of EUS-TD for POPF, although there is insufficient evidence regarding the performance of EUS-TD for POPF.

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  • This study focuses on pancreatic ductal adenocarcinoma (PDAC) patients and the impact of peritoneal lavage cytology (CY) on their prognosis, classifying patients into three groups based on CY results: negative (CY0), suspicious for malignancy (CY-S), and positive (CY1).
  • Findings reveal that patients in the CY1 group experienced significantly worse survival rates and more aggressive tumor characteristics than CY0 patients, while CY-S patients had similar characteristics to CY0.
  • Although CY-S was linked to an increased risk of peritoneal recurrence compared to CY0, patients in this group still showed relatively acceptable long-term outcomes post-surgery.
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Background: Transduodenal ampullectomy has been attempted in ampullary tumors, including early ampullary cancer. However, the indication and extent of transduodenal ampullectomy with curative intent remain controversial. Herein, we address the perioperative and long-term outcomes of patients with early ampullary cancer who underwent transduodenal ampullectomy at a single center.

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Three-dimensional surgical simulation, already in use for hepatic surgery, can be used in pancreatic surgery. However, some problems still need to be overcome to achieve more precise pancreatic surgical simulation. The present study evaluates the performance of SYNAPSE VINCENT® (version 6.

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Article Synopsis
  • There's an increasing number of reports on conversion surgery for patients with initially unresectable biliary tract cancer (BTC), meaning surgery can be performed after initial treatments.
  • Using gemcitabine plus cisplatin (GC) therapy has been shown to significantly extend survival for these patients, increasing median survival from 8.1 to 11.7 months compared to standard treatments.
  • A case study of a 78-year-old woman showed that after 6 cycles of GC therapy, she had a partial response, which allowed her to undergo successful conversion surgery without recurrence for 12 months.
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Background: The optimal lymph node (LN) dissection for left-sided pancreatic cancer based on tumor location has remained unknown. In particular, the efficacy of LN dissection around the common hepatic artery and the celiac axis for distal tumors has not been established. This study was designed to elucidate the frequency and prognostic impact of LN metastasis, focusing on tumor location.

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Background: Colloid carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreatic head with prominent calcification is exceedingly rare. Only a few studies about this entity have been reported in the literature. Therefore, its biological behavior, appropriate treatment modalities, and overall patient prognosis remain largely unclear.

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Background: Pancreatectomy may cause serious pancreatic exocrine insufficiency (PEI), which can lead to some nutritional problems, including new-onset diabetes mellitus (DM) or non-alcoholic fatty liver disease (NAFLD). Recent studies have reported that remnant pancreatic volume (RPV) significantly influences postoperative PEI. However, the specific correlation between RPV and postoperative PEI remains unclear.

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  • Laugier's hernia is a rare type of hernia compared to typical femoral hernias, making its clinical features and treatment less understood; this study analyzed 15 cases to fill these gaps.
  • The study involved a retrospective comparison between 15 Laugier's hernia patients and 89 femoral hernia patients, revealing significant differences in symptoms, hernia size, and contents.
  • For surgeons, recognizing the possibility of Laugier's hernia when treating patients with femoral or inguinal hernias is crucial, and preoperative multi-detector computed tomography (MDCT) is recommended for diagnosis.
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Postoperative pancreatic fistula (POPF) is a serious complication that can occur following distal pancreatectomy (DP). Recent studies demonstrated that the use of reinforced staplers with bioabsorbable mesh significantly reduced the incidence of POPF, although the safety and efficacy of this approach remain controversial. Therefore, we originally developed a modified closure technique that combines the use of a reinforced stapler with bioabsorbable mesh with suture closure of the main pancreatic duct.

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Background: In Japan, the significance and efficacy of preoperative chemotherapy alone for locally advanced rectal cancer remain controversial. This case report presents the apparent effectiveness of preoperative FOLFOX plus bevacizumab as shown by pathological complete response (pCR). Additionally, we review the relevant literature and discuss the clinical management of locally advanced rectal cancer with preoperative chemotherapy.

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Background: Remnant pancreatic volume (RPV) is a well-known marker for short-term outcomes in pancreatic cancer patients after resection. However, in terms of the long-term outcomes, the significance of the RPV value remains unclear. Here, we address whether the RPV value is a predictor of the long-term outcomes in pancreatic cancer patients after resection by comparing various cancer-, patient-, and surgery-related prognostic factors and systemic inflammatory response markers in a retrospective cohort.

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Background: Postoperative pancreatic fistula (POPF) is a serious complication that can occur following pancreaticoduodenectomy (PD). Recent studies suggest that remnant pancreatic volume (RPV) values from preoperative multidetector computed tomography (MDCT) are highly predictive of POPF. We performed three-dimensional (3D) surgical simulation of PD including RPV measurements.

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Background/aims: We evaluated the usefulness of three-dimensional (3D) images for pancreatoduodenectomy (PD), including the classification of the bile duct and vascular arrangement, i.e., hepatic artery, inferior mesenteric vein (IMV) and left gastric vein (LGV).

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Rationale: Gastric adenocarcinoma of fundic gland type (GA-FG) is a new histological type of gastric cancer manifesting with differentiation into a fundic gland. Furthermore, gastric adenocarcinoma of fundic gland mucosa type (GA-FGM) is a tumor that shows differentiation into not only a fundic gland but also foveolar epithelium and a mucous gland. These tumors tend to invade the submucosal layer.

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Background/aims: Anatomical variations are frequently encountered during hepato-biliary-pancreatic surgeries, requiring surgeons to have a precise understanding of the surgical anatomy in order to perform a safe surgery. We evaluated the impact of novel three-dimensional (3D) surgical simulation on pancreatic surgeries to enhance surgical residents' understanding.

Methodology: Between January 2013 and May 2014, 61 preoperative 3D surgical simulations were performed.

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Background: The preoperative neutrophil-to-lymphocyte ratio (NLR) is a well-known prognostic marker for gastric cancer patients. However, the utility of the NLR in predicting short-term outcomes in gastric cancer patients remains unclear. Here, we investigated whether the preoperative NLR is a predictor of short-term outcomes in gastric cancer patients.

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Background: Collision tumors, composed of histologically distinct tumor types, are rare entities, especially in the colorectum, and corresponding evidence-based clinical management or treatment strategies are poorly defined. This is the first report of a collision tumor composed of two histologically distinct adenocarcinomas.

Case Presentation: A 78-year-old male showed severe anemia and a 10% body weight loss over 1 month.

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Introduction: Sarcoidosis is a multisystem disease characterized by the presence of non-caseating granulomas in affected organs. Almost 70% of patients with a sarcoidosis reaction have hepatic involvement. However, evidence-based clinical management or treatment strategies for hepatic sarcoidosis are poorly defined.

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Introduction: During laparoscopic-assisted colorectal surgery (LACS) for right-sided colon cancer patients, we performed three-dimensional (3D) surgical simulation to investigate vascular anatomy, including the ileocolic artery (ICA), right colic artery (RCA) and superior mesenteric vein (SMV).

Aim: We also used 3D imaging to examine the shortest distance from the root of the ileocolic vein (ICV) to the gastrocolic trunk (GCT).

Material And Methods: We analyzed 46 right-sided colon cancer patients who underwent 3D-simulated LACS.

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Objectives: During laparoscopic-assisted colorectal surgery (LACS), precise recognition of the anatomic variations and relationships among tumor and vessels is required. However, in highly obese patients, it is more difficult to grasp the surgical anatomy due to the presence of dense mesenteric fat tissue. We utilized a 3-dimensional (3D) reconstructed image for preoperative simulation and intraoperative navigation for LACS.

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Background: In the past decade, three-dimensional (3D) simulation has been commonly used for liver surgery. However, few studies have analyzed the usefulness of this 3D simulation. The aim of this study was to evaluate the effect of 3D simulation on the outcome of liver surgery.

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