Publications by authors named "Ryohei Nakaguro"
Article Synopsis
- The study investigates how diet-induced obesity affects cognitive decline and white matter lesions (WMLs) linked to brain ischemia, focusing on neuroinflammation triggered by lipopolysaccharides (LPS) through toll-like receptor (TLR) 4.
- Wild-type and TLR4-knockout mice were fed either a high-fat or low-fat diet, then subjected to carotid artery narrowing to assess changes in inflammation and cognitive function.
- Results showed that diet-induced obesity exacerbated cognitive impairment and WML severity in wild-type mice, while TLR4-KO mice did not exhibit these effects, suggesting inflammation through LPS-TLR4 signaling plays a significant role in obesity-related cognitive issues.
(1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. (2) Methods: In the present study, we aimed to understand the relationship between the intestinal environment, including intestinal microbiome and their metabolome, and glucose tolerance.
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