Publications by authors named "Ryohei Kanamaru"
Article Synopsis
- - The study analyzed the impact of immunotherapy on 67 patients with unresectable stage IVB gastric cancer treated at Yarita Hospital, comparing outcomes from an early group (2016-2017) and a late group (2018-2022).
- - Nivolumab was administered to 30% of patients, with a median overall survival of 11 months, showing longer survival in the early group compared to the late group (13 vs. 8.5 months). Transition rates to third-line treatments also increased from 22% to 33% over the study period.
- - The findings suggest that the introduction of new therapies has improved treatment options for patients with advanced gastric cancer, indicating a trend towards better management
Background: Cholesterol (C) and cholesteryl esters (CE) within coronary plaques are minimally visualized directly by any of the available imaging modalities in vivo. If they are rendered visible in vivo, the progression of coronary plaques and the effects of respective therapies on these plaques can be objectively evaluated.
Hypothesis: The C and CE within human coronary plaques can be visualized by near-infrared fluorescence angioscopy (NIRFA).
Detection of vulnerable coronary plaques by color fluorescent angioscopy.
JACC Cardiovasc Imaging
April 2010
Objectives: This study was carried out to detect vulnerable coronary plaques by color fluorescent angioscopy.
Background: Collagen fibers (CFs) mainly provide mechanical support to coronary plaques. Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, which in turn destroy CFs while accumulating lipids.
Lysophosphatidylcholine (LPC) is a proinflammatory and proatherogenic substance, and it plays an important role in the initiation, progression, and destabilization of atherosclerotic plaques. If LPC in the vascular wall is visualized in vivo, the mechanisms of atherosclerosis and the effects of medical and interventional therapies on atherosclerosis can be objectively evaluated. Therefore, this study was carried out to visualize LPC in human coronary plaques using a color fluorescence angioscopy (CFA) system.
View Article and Find Full Text PDF