Publications by authors named "Ryo Yamaue"
Although respiratory syncytial virus (RSV) vaccine development initiatives have existed for half a century, no candidate has been approved for application at all ages from neonates to children. Developing an effective and safe RSV vaccine for pediatric use is challenging owing to RSV-associated disease and vaccine-enhanced disease (VED). We aimed to design an RSV vaccine, KD-409, by structurally incorporating the F ectodomain and G protein central conserved domain without the CX3C chemokine motif and test its efficacy and safety.
View Article and Find Full Text PDFArticle Synopsis
- Cytoplasmic RIG-I-like receptors (RLRs) in mammalian cells detect viral RNA to trigger an antiviral response and induce IFN-β, with MDA5 forming fibers along viral dsRNA to enhance this response.
- LGP2, a unique RLR that does not have a signaling domain, aids MDA5 in fiber formation and activates MDA5 by inducing conformational changes that expose its signaling components, the CARDs.
- The study shows that LGP2 serves as a crucial partner for MDA5, facilitating its activation and maintaining its active state even after the fibers dissociate, providing insights into how LGP2 regulates MDA5 during antiviral immune responses.