Mucopolysaccharide polysulfate increases local skin blood volume through nitric oxide production.

Background: Mucopolysaccharide polysulfate (MPS) is widely used as an active ingredient in topical preparations for the treatment of asteatosis and blood flow disorders. Although topical MPS products can increase cutaneous blood flow (CBF), the underlying mechanism remains unclear.

Objective: In this study, we aimed to elucidate how MPS increases CBF.