Publications by authors named "Ryo Sugawa"
Article Synopsis
- Skeletal muscle consists of diverse myofiber types, primarily classified as slow-twitch and fast-twitch, influenced by various genes, including Vgll2.
- Vgll2 null mice showed an increase in fast-twitch fibers and a decrease in slow-twitch MyHC gene expression, leading to difficulties in exercise.
- The study found a connection between Vgll2 and TEAD transcription factors, suggesting Vgll2 plays a crucial role in regulating slow muscle fiber development.
Embryonic stem cells are considered to be a good in vitro tool to study the induction of various cell types including cardiomyocytes; however, induction of the pharyngeal endoderm (PE), the underlying heart-forming region, in vivo has been scarcely reported. In the present study, we found that many PE-related genes, such as Paxl, Pax9, Sixl, and Tbxl, were up-regulated in cardiomyocyte-rich embryoid bodies (EBs). The third pouch-related genes including Hoxa3, Foxn1, and Aire, which are crucial for thymus development and function, were also detected in later stages.
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