Should nicorandil infusion be adapted in dialysis-dependent patients undergoing continuous renal replacement therapy after cardiac surgery?

In this report, we studied whether plasma concentration of nicorandil is maintained effectively and safely in dialysis-dependent patients with stage 5 chronic kidney disease (CKD5D) undergoing continuous renal replacement therapy (CRRT). Participants consisted of 10 patients undergoing CRRT after cardiac surgery. CRRT was performed with an effluent flow rate of either 600 mL/h (low-flow group; n = 5) or 1800 mL/h (high-flow group; n = 5).

Effect of hemopurification rate on doripenem pharmacokinetics in critically ill patients receiving high-flow continuous hemodiafiltration.

  Hemopurification is an effective therapy for acute kidney injury, defined as creatinine clearance less than 30 ml/min, which occurs frequently in the intensive care unit. These critically ill patients often have severe infectious complications and are thus often treated with antibiotics. However, the effect of hemopurification on the pharmacokinetics of antibiotics is not well understood.

[New technique for identification of the pulmonary segment using high frequency jet ventilation and bronchofiberscopy].

We report a simple and quick technique for the identification of the pulmonary segment using high frequency jet ventilation and bronchofiberscopy. During the pulmonary segmentectomy, we inserted a bronchofiberscope connected with the jet ventilator into endobronchial tube and inflated the pulmonary segment to be removed. This technique provided the clear identification of the pulmonary segment, but it can cause the barotrauma by hyperinflation and an expansion of an inappropriate other segment.