Publications by authors named "Ryo Bando"
Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell collection methods rely heavily on the enzymatic digestion of dissected DP tissue to isolate and propagate primary cells, which often results in low recovery rates and reduced cell survival, particularly from deciduous teeth.
View Article and Find Full Text PDFNeurofibromatosis type 1 (NF1) is an autosomal dominant multi-organ disease. The clinical manifestations include not only skin lesions and malignant tumors but also lung complications, including pulmonary arterial hypertension (PAH). However, the association between gene mutations in NF1 and the occurrence of PAH has not yet been elucidated.
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- Temporal specification of neural progenitors (NPs) is crucial for the proper formation of excitatory neurons in the cerebral cortex, as they transition from neuroepithelial cells to radial glia and shift from symmetric to asymmetric cell division.
- GABAARs and taurine play significant roles in this developmental process, with exposure to GABAAR-antagonists hindering the transition to radial glia and the production of upper-layer neurons, while GABAAR-agonists have the opposite effect.
- Disruption of taurine and GABAAR interactions can lead to behavioral changes in offspring, linking these processes to neurodevelopmental disorders, including autism.