Publications by authors named "Ryna Then"

Article Synopsis
  • A study was conducted to address the disparity in access to mechanical thrombectomy (MT) in low- to middle-income countries by organizing team-based workshops aimed at improving knowledge and skills related to MT for stroke treatment.
  • The workshops, held in Jamaica and the Dominican Republic, included didactic and hands-on training for neurointerventional teams, resulting in significant improvements in test scores and practical skills in managing strokes due to large vessel occlusion.
  • Feedback from participants indicated high satisfaction rates, with a majority believing that the training would positively impact their clinical practice.
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Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological condition that classically presents with recurrent, thunderclap headaches and radiographic findings of multifocal narrowing of cerebral vasculature. Complications of RCVS may include ischemic or hemorrhagic strokes. Sympathomimetic agents including cannabinoids have been associated as precipitants in many cases.

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Stroke is the leading cause of death and adult-onset disability in the Caribbean region. Despite the tremendous advances in acute stroke care in the past 25 years, treatment in the Caribbean lags stroke standards of care. Mission Thrombectomy 2020+ (MT2020+) is a metrics based global campaign focused on increasing access to organized stroke care and mechanical thrombectomy.

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Article Synopsis
  • - Nilotinib, a medication used to treat chronic myelogenous leukemia (CML), may lead to serious vascular problems like accelerated arterial stenosis, particularly atherosclerosis, which can result in conditions such as acute stroke, even in patients with no prior cardiovascular risk factors.
  • - The exact reasons why nilotinib triggers atherosclerosis are not well understood, but potential factors include issues with blood vessel linings, metabolism, and changes in fat and glucose levels.
  • - Healthcare providers should be vigilant about the possible risk of vascular diseases associated with nilotinib and consider screening for cardiovascular issues in patients before starting treatment, as well as monitoring them closely throughout the therapy.
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Objective: To characterize differences in disposition arrangement among rehab-eligible stroke patients at a Comprehensive Stroke Center before and during the COVID-19 pandemic.

Materials And Methods: We retrospectively analyzed a prospective registry for demographics, hospital course, and discharge dispositions of rehab-eligible acute stroke survivors admitted 6 months prior to (10/2019-03/2020) and during (04/2020-09/2020) the COVID-19 pandemic. The primary outcome was discharge to an inpatient rehabilitation facility (IRF) as opposed to other facilities using descriptive statistics, and IRF versus home using unadjusted and adjusted backward stepwise logistic regression.

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Background And Purpose: Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology.

Methods: We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20).

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Article Synopsis
  • The COVID-19 pandemic has significantly impacted medical care, specifically leading to delays in acute stroke treatment at comprehensive stroke centers in the U.S.!* -
  • A study evaluating stroke patients admitted during the pandemic showed lower odds of receiving timely thrombolysis treatment within the Target: Stroke goal of 60 minutes compared to the pre-COVID-19 period, with a median delay of 4 minutes noted.!* -
  • The findings indicated that delays were primarily due to slower imaging to treatment times, although there were no significant delays in thrombectomy procedures during the same period.!*
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Purpose: We hypothesized patients implanted with ILRs for cryptogenic stroke in "real life" clinical practice will show an AF detection rate comparable to prior clinical studies, and that clinical or imaging features may help to identify those at higher risk of AF detection.

Methods: A retrospective chart review was conducted of all patients who presented with cryptogenic stroke and received an ILR at an academic medical center from 2015 to 2017 with an active inpatient stroke service. The electronic health record and remote monitoring were used to identify occurrence of AF.

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Antiphospholipid syndrome (APLS) is an autoimmune condition that predisposes to venous and arterial thrombosis. Warfarin is the agent of choice for anticoagulation. However, a need for routine international normalised ratio (INR) checks and multiple drug interactions are some of the difficulties with warfarin.

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Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.

Aim: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.

Methods: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020-16 June 2020).

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Takayasu arteritis (TA) is a rare inflammatory arteritis that is usually affecting young women and causes ischemic changes in the vessel wall. In this report of TA leading to an acute ischemic stroke, we describe a treatment-resistant case, with short interval flares and the challenge of defining the stroke etiology as a large vessel occlusive disease vs. an arteritis flare.

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A 52-year-old woman with a medical history of cervical and thyroid cancer, hypertension, dyslipidaemia, uncontrolled diabetes and heavy smoking was diagnosed with a new metastatic cholangiocarcinoma. While undergoing palliative chemotherapy, she developed dysarthria and left-sided weakness. Imaging studies showed multiple bilateral ischaemic strokes.

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