Publications by authors named "Rym Aouameur"
SMIT2 mediates all myo-inositol uptake in apical membranes of rat small intestine.
Am J Physiol Gastrointest Liver Physiol
December 2007
This study presents the characterization of myo-inositol (MI) uptake in rat intestine as evaluated by use of purified membrane preparations. Three secondary active MI cotransporters have been identified; two are Na(+) coupled (SMIT1 and SMIT2) and one is H(+) coupled (HMIT). Through inhibition studies using selective substrates such as d-chiro-inositol (DCI, specific for SMIT2) and l-fucose (specific for SMIT1), we show that SMIT2 is exclusively responsible for apical MI transport in rat intestine; rabbit intestine appears to lack apical transport of MI.
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- Myo-inositol (MI) plays a key role in cell physiology, particularly in cell signaling and regulating intracellular osmolarity.
- Three MI cotransporters have been identified: two Na(+)-dependent (SMIT1 and SMIT2) and one H(+)-dependent (HMIT), with SMIT2 mainly found in the brain.
- The study found that in rabbit kidneys, SMIT1 is mostly in the medulla, while SMIT2 is predominantly in the cortex, suggesting SMIT2's role in transporting MI into the proximal tubule.