Characterizing the Relationships Amongst Psychological Safety, the Learning Environment, and Well-Being in Surgical Faculty and Trainees.

Objective: Learning environments affect the well-being of surgical faculty and trainees. Psychological safety (PS) has been linked with learning behaviors and aspects of well-being within medicine; however, given the unique challenges inherent to the surgical learning environment, there is a need to more closely examine these concepts for surgical faculty and trainees. The objective of this study is to examine the relationships between learning environment and PS, as well as PS and well-being with surgery.

RadOncCalc: A Mobile-Friendly Tool to Enhance Radiation Oncology Practice.

This study introduces RadOncCalc, a mobile and web-based platform designed to consolidate oncology research and guidelines into one accessible tool for radiation oncologists. By providing up-to-date dose constraints and contouring guidelines, RadOncCalc enhances clinical decision-making and patient care quality in radiation oncology.

Dose Planning and Radiation Optimization for Thoracic Conventional, Twice Daily, and Stereotactic Radiation Therapy: A Delphi Consensus From a National Survey of Practitioners.

Purpose: We sent surveys to a large number of radiation oncologists with active thoracic cancer practices and applied the Delphi method over 3 rounds to generate consensus dose-volume histogram metrics. We used these results to create consensus-based organs-at-risk dose constraints and target goal templates for practical implementation.

Methods And Materials: In this institutional review board-approved study, data were collected using REDCap electronic data capture on a secure server.

Timing of Surgical Intervention of Uncomplicated Pediatric Umbilical Hernias.

Pediatric umbilical hernias are common congenital defects that regularly close without intervention. When spontaneous closure fails to occur, surgical herniorrhaphy is the standard of care. However, there are currently no national consensus guidelines describing the appropriate minimum age of surgical intervention for umbilical hernias.

Open RT Structures: A Solution for TG-263 Accessibility.

Purpose: Consistency of nomenclature within radiation oncology is increasingly important as big data efforts and data sharing become more feasible. Automation of radiation oncology workflows depends on standardized contour nomenclature that enables toxicity and outcomes research, while also reducing medical errors and facilitating quality improvement activities. Recommendations for standardized nomenclature have been published in the American Association of Physicists in Medicine (AAPM) report from Task Group 263 (TG-263).

Explainable Artificial Intelligence to Identify Dosimetric Predictors of Toxicity in Patients with Locally Advanced Non-Small Cell Lung Cancer: A Secondary Analysis of RTOG 0617.

Purpose: Dosimetric predictors of toxicity in patients treated with definitive chemoradiation for locally advanced non-small cell lung cancer are often identified through trial and error. This study used machine learning (ML) and explainable artificial intelligence to empirically characterize dosimetric predictors of toxicity in patients treated as part of a prospective clinical trial.

Methods And Materials: A secondary analysis of the Radiation Therapy Oncology Group (RTOG) 0617 trial was performed.

Safety of Radiation Therapy in Patients With Prostate Cancer and Inflammatory Bowel Disease: A Systematic Review.

Purpose: Inflammatory bowel disease (IBD) has historically been considered a relative contraindication for pelvic radiation therapy (RT). To date, no systematic review has summarized the toxicity profile of RT for patients with prostate cancer and comorbid IBD.

Methods And Materials: A PRISMA-guided systematic search was conducted on PubMed/Embase for original investigations that reported gastrointestinal (GI; rectal/bowel) toxicity in patients with IBD undergoing RT for prostate cancer.

Radiation-induced inferior brachial plexopathy after stereotactic body radiotherapy: Pooled analyses of risks.

Introduction: Radiation-induced brachial plexopathy (RIBP), resulting in symptomatic motor or sensory deficits of the upper extremity, is a risk after exposure of the brachial plexus to therapeutic doses of radiation. We sought to model dosimetric factors associated with risks of RIBP after stereotactic body radiotherapy (SBRT).

Methods: From a prior systematic review, 4 studies were identified that included individual patient data amenable to normal tissue complication probability (NTCP) modelling after SBRT for apical lung tumors.

American Society of Clinical Oncology 2022 Annual Meeting Highlights for Radiation Oncologists.

The American Society of Clinical Oncology annual meeting is the largest multidisciplinary oncology-focused conference in the world. With almost 5000 total abstracts in 2022, it is difficult for individuals to evaluate all the results. Here we present a review of 28 selected abstracts, across all disease sites, focusing on those of greatest relevance to radiation oncologists.

Hypofractionated Stereotactic Radiation Therapy Dosimetric Tolerances for the Inferior Aspect of the Brachial Plexus: A Systematic Review.

We sought to systematically review and summarize dosimetric factors associated with radiation-induced brachial plexopathy (RIBP) after stereotactic body radiation therapy (SBRT) or hypofractionated image guided radiation therapy (HIGRT). From published studies identified from searches of PubMed and Embase databases, data quantifying risks of RIBP after 1- to 10-fraction SBRT/HIGRT were extracted and summarized. Published studies have reported <10% risks of RIBP with maximum doses (D) to the inferior aspect of the brachial plexus of 32 Gy in 5 fractions and 25 Gy in 3 fractions.

Scalable and CMOS compatible silicon photonic physical unclonable functions for supply chain assurance.

We demonstrate the uniqueness, unclonability and secure authentication of N = 56 physical unclonable functions (PUFs) realized from silicon photonic moiré quasicrystal interferometers. Compared to prior photonic-PUF demonstrations typically limited in scale to only a handful of unique devices and on the order of 10 false authentication attempts, this work examines > 10 inter-device comparisons and false authentication attempts. Device fabrication is divided across two separate fabrication facilities, allowing for cross-fab analysis and emulation of a malicious foundry with exact knowledge of the PUF photonic circuit design and process.

Roughness Suppression in Electrochemical Nanoimprinting of Si for Applications in Silicon Photonics.

Metal-assisted electrochemical nanoimprinting (Mac-Imprint) scales the fabrication of micro- and nanoscale 3D freeform geometries in silicon and holds the promise to enable novel chip-scale optics operating at the near-infrared spectrum. However, Mac-Imprint of silicon concomitantly generates mesoscale roughness (e.g.

Local Treatment of the Primary Tumor for Patients With Metastatic Cancer (PRIME-TX): A Meta-Analysis.

Purpose: Local treatment of the primary tumor for patients with metastases is controversial, and prospective data across many disease sites have conflicting conclusions regarding benefits.

Methods And Materials: A comprehensive search was conducted in PubMed/MEDLINE including randomized controlled trials (RCTs) published in the past 50 years. Inclusion criteria were multi-institutional RCTs of patients with metastatic disease receiving systemic therapy randomized to addition of local treatment to the primary tumor.

The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes.

Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer.

Introduction: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been examined in other sites commonly treated with SBRT.

Hyperchromatic structural color for perceptually enhanced sensing by the naked eye.

Colorimetric sensors offer the prospect for on-demand sensing diagnostics in simple and low-cost form factors, enabling rapid spatiotemporal inspection by digital cameras or the naked eye. However, realizing strong dynamic color variations in response to small changes in sample properties has remained a considerable challenge, which is often pursued through the use of highly responsive materials under broadband illumination. In this work, we demonstrate a general colorimetric sensing technique that overcomes the performance limitations of existing chromatic and luminance-based sensing techniques.

Multifunctional focusing and accelerating of light with a simple flat lens.

The wavefronts emerging from phase gradient metasurfaces are typically sensitive to incident beam properties such as angle, wavelength, or polarization. While this sensitivity can result in undesired wavefront aberrations, it can also be exploited to construct multifunctional devices which dynamically vary their behavior in response to tuning a specified degree of freedom. Here, we show how incident beam tilt in a one dimensional metalens naturally offers a means for changing functionality between diffraction limited focusing and the generation of non-paraxial accelerating light beams.

Design of ultra-small mode area all-dielectric waveguides exploiting the vectorial nature of light.

The wave nature and diffraction of light pose a significant bottleneck to the continued performance and efficiency scaling of a wide variety of integrated photonic devices, often necessitating solutions based on resonance, slow-light, or plasmonics to derive enhanced light-matter interaction. Here, we introduce all-dielectric waveguides that exploit the vectorial nature of light to achieve strong subdiffraction confinement in high index dielectrics, enabling characteristic mode dimensions below 02/1000 without metals or plasmonics. We further show how these ultra-small mode areas may coincide or diverge from the nonlinear effective mode area.

Correlation of dosimetric factors with the development of symptomatic radiation pneumonitis in stereotactic body radiotherapy.

Background: The development of radiation pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT) is known to be associated with many different factors, although historical analyses of RP have commonly utilized heterogeneous fractionation schemes and methods of reporting. This study aims to correlate dosimetric values and their association with the development of Symptomatic RP according to recent reporting standards as recommended by the American Association of Physicists in Medicine.

Methods: We performed a single-institution retrospective review for patients who received SBRT to the lung from 2010 to 2017.

Single-mode porous silicon waveguide interferometers with unity confinement factors for ultra-sensitive surface adlayer sensing.

Guided wave-optics has emerged as a promising platform for label free biosensing. However, device sensitivity toward surface-bound small molecules is directly limited by the evanescent interaction and low confinement factor with the active sensing region. Here, we report a mesoporous silicon waveguide design and inverse fabrication technique that resolves the evanescent field interaction limitation while achieving maximal transverse confinement factors and preserving single-mode operation.

Radiomic feature stability across 4D respiratory phases and its impact on lung tumor prognosis prediction.

Radiomic analysis has recently demonstrated versatile uses in improving diagnostic and prognostic prediction accuracy for lung cancer. However, since lung tumors are subject to substantial motion due to respiration, the stability of radiomic features over the respiratory cycle of the patient needs to be investigated to better evaluate the robustness of the inter-patient feature variability for clinical applications, and its impact in such applications needs to be assessed. A full panel of 841 radiomic features, including tumor intensity, shape, texture, and wavelet features, were extracted from individual phases of a four-dimensional (4D) computed tomography on 20 early-stage non-small-cell lung cancer (NSCLC) patients.

Concurrent Versus Sequential Chemoradiation for Low-grade Gliomas Meeting RTOG 9802 Criteria.

Purpose: Radiation Therapy Oncology Group (RTOG) 9802 has established postoperative radiation therapy (RT) and chemotherapy sequentially as the new standard of care for patients with high-risk low-grade glioma (LGG) meeting trial criteria. Although this trial investigated sequential chemoradiation therapy (sCRT) with RT followed by chemotherapy, it is unknown whether concurrent chemoradiation therapy (cCRT) may offer advantages over sCRT.

Materials And Methods: The National Cancer Database (NCDB) was queried for newly diagnosed World Health Organization (WHO) grade II glioma.