[Prediction of the effect of neoadjuvant chemotherapy in patients with non-small cell lung cancer of stage III at phases of combined treatment].

We examined 100 patients with non-small cell lung cancer (NSCLC). In addition to surgery there was performed neoadjuvant chemotherapy (2-3 cycles) EP (cisplatin at a dose of 80 mg/m2 on first day + etoposide at a dose of 120 mg/ m2 on days 1,3,5). There were studied the levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) as prognostic factors in the use of neoadjuvant chemotherapy in patients with NSCLC.

[The immediate results of bronchoplastic surgical operations in surgery for lung malignant tumors].

Bronchoplastic surgical operations by means of invaginated method on 1 semicircle in lung malignant tumors were performed in 124 patients. Of them 116 patients (93,5%) had primary and 8 patients (6,5%) metastatic tumors. There were 94 men (75,8%) and 30 women (24,2%).

[Optimization of treatment methods of surgical complications in lung cancer].

The present report analyses the immediate and long-term results of treatment of surgical complications in 998 patients with lung cancer. There were complications in 37,5% of the cases, with a fatality rate of 14,7%. The most frequent complications were as follows: postoperative empyema with bronchopleural fistula (41,3%), bleeding (12,0%), pneumonia (9,8%), pulmonary arteries embolism (8,1%) and heart rhythm disorders (8,1%).

[Bronchopleural fistula--risk factors, prophylactics and treatment in oncopulmanology].

The problem in question is actual because of great incidence of postoperative complications and considerable problems with treatment of them. The authors made an analysis of surgical treatment of 506 patients with primary cancer and carcinoid tumors of the lung. The authors have developed a system of individual prognosis of risk of the development of bronchopleural fistulas (BPF), introduced an original technique of bronchomyoplasty with the help of m.

[Genotypic and phenotypic markers in patients with chronic obstructive bronchitis].

The study included examination of 120 patients with chronic obstructive bronchitis (COB) and 70 healthy people. The following genotypic and phenotypic markers were evaluated: blood group, Rhesus factor, earwax type, constitution, height, iris color, hair color, signs of functional asymmetry and some minimal signs of embryogenesis disturbances. The relative risk of the disease development was counted for each parameter.

[Kanamycin deposition in the peritoneum as affected by dimexide].

The effect of dimexid (dimethylsulfoxide) on kanamycin absorption from the peritoneum was studied on normal albino rats with aseptic peritonitis. Contrary to the present opinion that the rate of various drug absorption into the blood increases under the effect of dimexid, it was shown that intraperitoneal administration of dimexid and kanamycin resulted in deposition of kanamycin in the peritoneum followed by its slow liberation into the blood channel. The concentration of kanamycin in the peritoneum increased 3--8 times under the effect of dimexid, thus prolonging its retention time by 10--13 hours.