Recent Advances in the Development of Bioreactors for Manufacturing of Adoptive Cell Immunotherapies.

Harnessing the human immune system as a foundation for therapeutic technologies capable of recognizing and killing tumor cells has been the central objective of anti-cancer immunotherapy. In recent years, there has been an increasing interest in improving the effectiveness and accessibility of this technology to make it widely applicable for adoptive cell therapies (ACTs) such as chimeric antigen receptor T (CAR-T) cells, tumor infiltrating lymphocytes (TILs), dendritic cells (DCs), natural killer (NK) cells, and many other. Automated, scalable, cost-effective, and GMP-compliant bioreactors for production of ACTs are urgently needed.

Subjective Trusts for the Control of Mobile Robots under Uncertainty.

The paper deals with the methods of handling imperfect information and the control of mobile robots acting under uncertainty. It is assumed that the robots act in autonomous regime and are controlled internally without referring the externally defined probabilities of the states and actions. To control the activity of the robots, we suggest the novel multi-valued logic techniques based on the recently developed measures, known as the subjective trusts.

Full reinforcement operators in aggregation techniques.

We introduce the concept of upward reinforcement in aggregation as one in which a collection of high scores can reinforce or corroborate each other to give an even higher score than any of the individual arguments. The concept of downward reinforcement is also introduced as one in which low scores reinforce each other. Our concern is with full reinforcement aggregation operators, those exhibiting both upward and downward reinforcement.

[Evaluation of the results of epicardial electric pulse destruction of the bundle of Kent: immediate and late results].

The authors assessed the outcomes of an epicardial electrical pulse destructive operation on Kent's bundle in 170 patients with the Wolff-Parkinson-White syndrome. The operation consisted in generating an electrical stimuli train of a power of 50-250 J along the fatty tenial margin of the atrioventricular sulcus, which damaged or isolated Kent's bundle. By refining the indications for application of the method, the authors succeeded in achieving 98% efficacy in abolishing the Kent bundle conduction in the absence of deaths in the latter group of patients.

[Epicardial mapping in the syndrome of premature ventricular excitation. 2].

Epicardial mapping was carried out in 20 patients suffering from Wolff-Parkinson-White's syndrome with supraventricular tachycardias resistant to drug therapy. The automated mapping system elaborated at the A.N.

[Epicardiac mapping in premature ventricular excitation syndrome. I. Method and technic of epicardiac mapping].

Using specially designed electrodes, an automated system for arrhythmia diagnosis and an all-purpose programmed electrocardiostimulator, the authors succeeded in obtaining a precise real-time chart of the electrical excitation distribution on the heart surface. The system was tested during open heart surgery in patients with congenital heart disease.

[Use of cryogenic technic in the diagnosis and treatment of cardiac rhythm disorders].

The repeated cryodestruction technique was used in disordered cardiac rhythm. A calculation of cryodestruction regimens for a specific operation was made. The cryogenic apparatus fitted with a core-thermoresistance monitor can be efficiently applied to the diagnosis and surgical treatment of cardiac rhythm disturbances.

[Analysis of probabilistic characteristics of brain biopotentials in healthy humans using electronic computer technology].

Results are given of determination by means of a Minsk-22 electronic computer of the probabilistic characteristics and correlation coefficients for some parameters of the background EEG (frontal-occipital records) in a group of healthy subjects. The parameters studied (the number and amplitude of alpha- and other waves) are subject to the normal law of distribution of random values. A probabilistic model of background EEG has been plotted.

[Cytoplasmic cross links of erythrocytes (observations in scanning electron microscopy)].

Erthyrocytes can form cytoplasmatic bridged connecting with each other individual cells or a great number of cells into a conglomerate. The cytoplasmatic bridges--is a peculiar form of existance of erythrocytes which differ from the forms described earlier: thorm-like (spheroechinocytes) and myelino-like forms having nothing in common with the mechanism of agglutination. The cytoplasmatic bridges of erythrocytes were found in man, dogs and guinea-pigs irrespective of a disease or conditions of an experiment, i.