Nanopore Data-Driven Chromosome-Level Assembly of Flax Genome.

Flax is an important crop grown for seed and fiber. Flax chromosome number is 2n = 30, and its genome size is about 450-480 Mb. To date, the genomes of several flax varieties have been sequenced and assembled.

[Effect of comorbid depression on the development and course of alcohol dependence].

It was compared 72 patients with alcohol dependence (AD) and endogenous depression (ED) and 30 patients with AD without comorbid affective pathology. It has been shown that the development of alcohol dependence in individuals with ED is slower than in patients without ED. A lack of a family history of addictive pathology was noted to be a predictor of a more favorable course of alcohol dependence in patients with ED.

Psychiatric disposition of patients brought in by crisis intervention team police officers.

Background: As part of an effort to improve police interactions with mentally ill citizens, and improve mental health care delivery to subjects in acute distress, the University of Louisville, in conjunction with the Louisville Metro Police, established the crisis intervention team (CIT). CIT is composed of uniformed officers who receive extensive training in crisis intervention and psychiatric issues and who are preferentially called to investigate police calls that may involve a mentally ill individual.

Methods: In an effort to determine the characteristics of the individuals brought to the emergency psychiatric service (EPS) by CIT officers, a comparative (CIT vs.

[The correction of the liver detoxifying function with phenobarbital and ziksorin before and after ischemia].

Rat experiments have shown preliminary administration of phenobarbital and zixoryn (before ischemia) fails to prevent the hepatic monoxygenase system from ischemic lesion, followed by profound destructive changes in the liver, though the functional activity of the microsomal system remained high. Phenobarbital and zixoryn induction of monooxygenases in the postischemic period contributed to the complete restoration of the levels of microsomal cytochromes and the metabolic activity of xenobiotics in the liver just in its early periods. It is concluded that it is advisable to use the inductors in the postischemic restorative period to correct the detoxifying function of the liver.

[The aldehyde dehydrogenase activity in the erythrocytes of alcoholic patients].

Red cell aldehyde dehydrogenase (ALDH, EC 1.2.1.

[Dynamics of activity of creatine kinase and its isoenzymes in the serum of patients with alcoholism].

Activity of creatine kinase (CK) and its isoenzymes was studied in blood serum of 32 patients with alcohol abstinent syndrome of various severity as well as in persons with long-term remission (from 1 to 14 years) as compared with the enzymatic activity in healthy volunteers. The severity of alcohol abstinent syndrome correlated with an increase in the total enzyme activity in blood, where content of the all three CK isoenzymes (MM, MB and BB), especially of BB-CK, was elevated. Content of MB and BB isozymes was increased in blood of patients with long-term remission, while activity of each of the isozyme constituted up to 20-30% of total CK activity, which was by one decimal order higher as compared with control values.

[Functioning of the monooxygenase system of the liver in experimental myocardial infarct].

The experiments on rats have shown that coronary artery ligation reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine-N-demethylation and aniline-p-hydroxylation disturbances that persist throughout a 3-week period of myocardial infarction. The investigation of spontaneous lipid peroxidation of microsomal membranes in myocardial infarction has shown that concentration of malonic dialdehyde in microsomal fraction significantly increased by the 7th day after coronary artery ligation, as compared to sham-operated rats.

[Changes in dexamethasone test indices and reduction in the rate of serotonin absorption by thrombocytes in chronic alcoholics].

Seventy-one chronic alcoholics with affective disorders were studied for the dexamethason test (DT) and for the rate of platelet serotonin absorption (RPSA) prior to and following the treatment. A considerable part of the patients displayed pathological changes in DT which correlated with the degree of affective symptomatology. The DT may serve as one of the methods for diagnosing affective disturbances in alcoholism.

Peculiarities of influenza infection caused by highly and poorly immunogenic strains of influenza virus.

The authors studied the peculiarities of the course of experimental influenza infection induced by the administration of highly and poorly immunogenic strains of influenza virus to mice. Influenza viruses with varying immunogenic activity were obtained from the vaccine strain A/Victoria/35/72/50 (H3N2) by immunoselection modelling the process of natural selection. The administration of strains with high and poor immunogenicity to mice of the F1 (CBA X C57B1) line led to the development of acute influenza infection accompanied by reproduction of viruses in the tissue of the lungs and other internal organs.

[Determination of the degree of antigenic novelty and of the epidemic currency of influenza virus strains].

A simple, practically feasible method based on neutralization of viruses with antibodies present in pools of placental immunoglobulin followed by their reactivation from the complex has been proposed for objective evaluation of the protection of the population against circulating variants of influenza virus and preliminary assessment of their antigenic novelty. The data obtained by this method show that the study may be done within a comparatively short period and will give an objective evaluation of the antigenic novelty and epidemic importance of various influenza virus strains with reference to the immunological status of the population in a definite region which permits one not only to determine the epidemic hazard of the strains for the present time but also to prognosticate it for the future.