Belarusian Healthcare Professionals' Views on Monkeypox and Vaccine Hesitancy.

Background: Despite the low transmission risk of Monkeypox (mpox) in Belarus, this study is vital as it contributes to our understanding of vaccine hesitancy among healthcare professionals (HCPs). It aims to assess vaccination perceptions and evaluate the willingness to pay for the vaccine among Belarusian HCPs, thereby enhancing pandemic preparedness.

Methods: in October 2022, a cross-sectional survey-based study was conducted among Belarusian HCPs using a self-administered questionnaire (SAQ).

[X-ray criteria for assessing the activity of lung sarcoidosis at follow-up].

The results of comprehensive X-ray findings in 300 patients with different clinical and X-ray forms of respiratory sarcoidosis who had been registered to be followed up at the Consulting Outpatient Department, Central Research Institute of Tuberculosis Russian Academy of Medical Sciences, were analyzed. The follow-up lasted 3 to 20 years. X-ray study heads the list of the most informative techniques for assessing the activity of sarcoidosis.

[Combined manifestations of natural foci in the territory of the Vologda province].

Based on epizootological and epidemiological investigations in the Vologda province since 1958 till 2000, the combined territorial and temporal manifestations of natural foci of diseases was revealed. A natural focus occupies a complex of biotopes, and in different time the focus is activated in different areas, such as a river plain, marsh, meadow-field, and forest. Most commonly an activation of the natural focus appears in a border zone of three biotopes, namely, a forest, meadow-field, and river plain.

[Comparative evaluation of the effectiveness of traditional and combined therapies of patients with sarcoidosis].

Treatments were comparatively analyzed in two groups comprising 106 patients with respiratory sarcoidosis. One group of patients (n = 52) was treated with conventional therapy (corticosteroid hormones as tablets or aerosols, physiotherapy, SWF, plaquenil, antioxidants, the other (n = 54) received combined therapy (plasmapheresis, reduced hormone dosage, antioxidants. With both treatments, the early results of treatment were equally positive in 60-63% of patients, mainly in new cases of sarcoidosis.

[Clinical presentation, course and treatment of recurrent sarcoidosis: followup data].

The paper presents the results of long-term follow-ups of 107 patients with recurrent sarcoidosis registered as having Group VII-IB. In the patients, there was the greatest dissemination of the process in the lung, intrathoracic lymph nodes and other organs and MF MB in the blood, sputum, BAC? Group VIIIB patients need the greatest attention of physicians, treatment involving extracorporeal and physiotherapeutical methods to prevent respiratory failure and disability.

[Follow-up of sarcoidosis outpatients].

The results of long-term follow-ups of 300 patients with sarcoidosis registered at the Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences, were studied. The paper provides a full characterization of the patients by their social status, clinical forms, detection modes, diagnostic methods. The efficiency of treatment was evaluated, as evidenced by the "movement" from group to group (from active group to inactive one).

[Further study of hantavirus circulation in the Russian Federation].

Lung specimens of 1514 small mammals of 35 species captured in 1991-1995 at 9 territories of Russia were tested in ELISA for virus antigens of hemorrhagic fever with the renal syndrome (HFRS). The antigens were detected in lung specimens of Clethrionomys glareolus, Microtus arvalis, Microtus gregalis, Microtus fortis, Arvicola terrestris, Apodemus agrarius, Micromys minutus, and Sorex sp., well known as Hantavirus reservoirs, captured in the Vologda, Yaroslavl, Saratov, Astrakhan, and Chita regions.

[Cardiac involvement in central lung cancer].

An x-ray picture of central lung cancer was analyzed in 34 operated patients in whom tumors had infiltrated the myocardium (left atrial infiltration in 33, right atrial infiltration in one, ventricular infiltration in 2). The comparison of x-ray findings with gross specimens of the removed lungs showed that tumor mass consisted of a primary tumor and metastatic bronchopulmonary lymph nodes that made impossible the differentiation of separate elements of the root x-ray image. Angiography was performed in 15 patients with suspected infiltration of the heart by a tumor on the basis of x-ray findings.

[Relapse of Q fever in childbirth and transmission of the pathogen to the child].

A case was described when a newborn was inoculated with Coxiella Burnetti as a result of infection relapse (in 8 months after acute disease) in his mother. Coxiella Burnetii were isolated from blood of both patients. Dynamics of humoral immunity indices in mother was observed both at the primary disease and during the period of infection relapse.

[An epidemiologic projection of foci of Q fever within herds].

In one of the rural regions of the nonchernozem zone retrospective epidemiological diagnosis was carried out in connection with high morbidity rates in acute respiratory diseases and influenza. This diagnosis was shown to cover cases of Q fever. Altogether 172 cases of this infection were retrospectively diagnosed.

[Use of modified Ayling's method for detection of homozygotes and heterozygotes for phenylketonuria gene].

Activity of phenylalanine hydroxylase from human leukocytes was shown to depend on concentration of phenylalanine and pteridine cofactor; optimal concentrations of the substances were estimated. Using this optimized procedure activity of phenylalanine hydroxylase was studied in leukocytes of homo- and heterozygotes by the phenylketonuria gene as well as in the cells of donors. The mean values of the enzymatic activity were distinctly different in the groups of homo-, heterozygote-bearing patients and in healthy persons, although a slight overlapping of the patterns was observed between the groups.

[Effect of venous congestion on the microcirculatory bed of rat adrenal glands].

Early effect of experimentally induced venous congestion on the rat adrenals is evident in dynamical changes in the microcirculatory bed of the glands. As morphometric data demonstrate, the greatest changes take place in blood vessels of the cortical substance: the capillary diameters are dilated in all the zones, the thickness of the wall in subcapsular and capsular arterioles increases at the expense of hypertrophic smooth muscle elements. Subsequently, venous-arteriolar reaction develops, with capillary diameter approaching the initial size.

[Incidence among children of Candida yeast-like fungi].

The incidence of Candida fungi in healthy children and those suffering from noninfectious diseases was studied. In dealthy children--from the time of birth to 7 years--it constituted 39%, and in sick children treated with antibiotics--53%. Dependence of the frequency of Candida fungi state on age was revealed; there was also a correlation between the amount of the fungi and the presence of lesions on the oral mucosa.