Neuronal somata and extrasomal compartments play distinct roles during synapse formation between Lymnaea neurons.

Proper synapse formation is pivotal for all nervous system functions. However, the precise mechanisms remain elusive. Moreover, compared with the neuromuscular junction, steps regulating the synaptogenic program at central cholinergic synapses remain poorly defined.

Synapse formation and plasticity: the roles of local protein synthesis.

From simple reflexes in lower animals to complex motor patterns and learning and memory in higher animals, all nervous system functions hinge upon fundamental, albeit specialized, neuronal units termed synapses. The term synapse denotes the structural and functional building block upon which pivots the enormous information-processing capabilities of our brain. It is the neuronal communications through synapses that ultimately determine who we are and how we react and adapt to our ever-changing environment.