Publications by authors named "Ryann Russell"
Article Synopsis
- Vaccine thermal stability relies on formulation factors like pH and ionic strength, which can be predicted based on scientific knowledge and experience.
- Support from experimental data is necessary for regulators to validate stability claims, as predictions alone are insufficient.
- The Design of Experiment (DoE) approach enables deeper understanding of how these formulation factors affect thermal stability, even in cases where the underlying mechanisms are not fully understood; this was exemplified in a study of an aluminum adjuvant vaccine showing formulation differences within just 15 days.
Trivalent native outer membrane vesicles (nOMVs) derived from three genetically modified Neisseria meningitidis serogroup B strains have been previously evaluated immunologically in mice and rabbits. This nOMV vaccine elicited serum bactericidal activity (SBA) against multiple N. meningitidis serogroup B strains as well as strains from serogroups C, Y, W, and X.
View Article and Find Full Text PDFLysins are peptidoglycan hydrolases that are produced by bacteriophage and act to lyse the bacterial host cell wall during progeny phage release. Here, we describe the structure and function of a novel bacteriophage-derived lysin, PlyB, which displays potent lytic activity against the Bacillus anthracis-like strain ATCC 4342. This molecule comprises an N-terminal catalytic domain (PlyB(cat)) and a C-terminal bacterial SH3-like domain, SH3b.
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