Modeling the Dynamics of a Secondary Neurodegenerative Injury Following a Mild Traumatic Brain Injury.

During a traumatic brain injury (TBI), there is an injection of glial fibrillary acidic protein (GFAP) from the brain into the bloodstream through a lesion in the blood-brain barrier (BBB). In the blood, a bio controller responds by up-regulating Immunoglobulin G (IgG) production into the bloodstream to remove the excess protein. Here, we model the concentrations over time of GFAP and IgG in the bloodstream following a mild TBI.