Publications by authors named "Ryan Whitty"
Background: Innovations in models of care for older adults living with frailty presenting to the emergency department (ED) have become a key priority for clinicians, researchers and policymakers due to the deleterious outcomes older adults experience due to prolonged exposure to such an environment. This study aimed to develop a set of expert consensus-based statements underpinning operational design, outcome measurement and evaluation of a Frailty at the Front Door (FFD) model of care for older adults within an Irish context.
Methods: A modified real-time Delphi method was used.
The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis.
PLoS Med
October 2020
Article Synopsis
- Understanding treatment delays for uncomplicated malaria (UM) is crucial as delays can increase the risk of developing severe malaria (SM).
- A meta-analysis involving 13 studies with nearly 4,000 SM patients and over 5,700 UM cases found that longer delays in treatment are significantly linked to higher odds of severe disease, particularly in children.
- The findings suggest that quicker access to treatment could potentially reduce the incidence of severe malaria, emphasizing the importance of effective treatment interventions like 'test-and-treat' policies.
Article Synopsis
- - The study evaluated the performance of ten quick lateral flow assays and two lab-based tests for detecting antibodies against SARS-CoV-2, focusing on the time after symptom onset and previous test samples.
- - It found that seropositivity increased over time, peaking over 20 days after symptoms began, but test specificity varied between 84.3% and 100%, mainly influenced by IgM results.
- - Recommendations from the study emphasize optimizing seropositivity thresholds and ensuring proper reader training to improve the reliability of these assays, with four tests showing over 80% positivity and over 95% specificity in later time intervals.
Background: Serological tests are crucial tools for assessments of SARS-CoV-2 exposure, infection and potential immunity. Their appropriate use and interpretation require accurate assay performance data.
Method: We conducted an evaluation of 10 lateral flow assays (LFAs) and two ELISAs to detect anti-SARS-CoV-2 antibodies.
Physical Preparation Factors That Influence Technical and Physical Match Performance in Professional Australian Football.
Int J Sports Physiol Perform
September 2018
Objectives: To examine the collective influence of a range of physical preparation elements on selected performance measures during Australian football match play.
Design: Prospective and longitudinal.
Methods: Data were collected from 34 professional Australian football players from the same club during the 2016 Australian Football League competition season.
We have investigated the mechanism by which the complement protease, Factor D, achieves its high specificity for the cleavage of Factor B in complex with C3(H2O). Kinetic experiments showed that Factor B and C3(H2O) associate with a KD of >/=2.5 microM and that Factor D acts on this complex with a second-order rate constant of kcat/KM >/= 2 x 10(6) M-1 s-1, close to the rate of a diffusion-controlled reaction for proteins of this size.
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