Publications by authors named "Ryan Way"
Article Synopsis
- Epithelial cells form protective barriers in the body, and leaky gut can lead to chronic inflammatory diseases.
- The study introduces a microphysiological system that monitors real-time barrier permeability of mouse colon tissue in a lab setting, preserving its natural environment for extended periods.
- The system utilizes advanced techniques like a microfluidic chamber and integrated sensors to effectively measure changes in barrier permeability, demonstrating the ability to maintain tissue function for up to 72 hours under various conditions.
Well plates are widely used in biological experiments, particularly in pharmaceutical sciences and cell biology. Its popularity stems from its versatility to support a variety of fluorescent markers for high throughput monitoring of cellular activities. However, using fluorescent markers in traditional well plates has its own challenges, namely, they can be potentially toxic to cells, and thus, may perturb their biological functions; and it is difficult to monitor multiple analytes concurrently and in real-time inside each well.
View Article and Find Full Text PDFEpithelial cells create barriers that protect many different components in the body from their external environment. The gut in particular carries bacteria and other infectious agents. A healthy gut epithelial barrier prevents unwanted substances from accessing the underlying lamina propria while maintaining the ability to digest and absorb nutrients.
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