Publications by authors named "Ryan Treadwell"
Article Synopsis
- Multiple multicomponent reactions are effective at quickly creating complex structures but often lack selectivity and have limited transformations for wider use in synthesis.
- The study proposes a method to enhance selectivity by generating less reactive intermediates from the starting materials.
- By utilizing this selective approach with the Groebke-Blackburn-Bienaymé reaction, researchers successfully produced various compact heterocyclic compounds with significant potential for applications in medicinal and biological chemistry, such as probes for live cell imaging and antiviral agents.
An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg without interference from Ca is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.
View Article and Find Full Text PDF