Publications by authors named "Ryan Shun-Yuen Kwan"
Article Synopsis
- Diabetic retinopathy (DR) is a severe eye complication linked to diabetes, driven by systemic inflammation and oxidative stress; the neutrophil-lymphocyte ratio (NLR) serves as a potential indicator of immune activity and may predict DR incidence.
- A study analyzed data from over 23,000 individuals with type 2 diabetes to assess the impact of NLR on developing DR, using advanced statistical models to account for factors like mortality.
- The findings revealed that a higher NLR (optimal cut-off at 3.04) correlated with increased risk of DR, with 35.8% of subjects developing the condition over 10 years, indicating NLR's significance as a prognostic biomarker in diabetes-related eye health
Changes in -regulatory DNA sequences and transcription factor (TF) repertoires provide major sources of phenotypic diversity that shape the evolution of gene regulation in eukaryotes. The DNA-binding specificities of TFs may be diversified or produce new variants in different eukaryotic species. However, it is currently unclear how various levels of divergence in TF DNA-binding specificities or motifs became introduced into the -regulatory DNA regions of the genome over evolutionary time.
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