Publications by authors named "Ryan Ponticelli"
Article Synopsis
- - The regulation of SIRT1 is crucial for maintaining energy balance and is involved in various diseases, particularly how insulin interacts with it through DBC1 and PACS-2 to inhibit activity.
- - Research reveals that the DBC1/PACS-2 complex in the liver manages SIRT1's daily activity, essential for switching fuel use from fat to glucose in response to insulin.
- - Acetylation and phosphorylation of specific amino acids in DBC1 and SIRT1 affect their interaction, with implications for diseases like obesity and fatty liver disease if the regulatory pathway fails.
