Publications by authors named "Ryan Pileski"
Article Synopsis
- Niacin, an agonist of the hydroxycarboxylic acid receptor 2 (HCA2), has been used for a long time to treat dyslipidemia but commonly causes skin flushing as a side effect.
- Researchers have been trying to find new HCA2-targeting agents that lower lipids without adverse effects, although the exact signaling mechanisms of HCA2 have not been well understood.
- This study presents the detailed structures of HCA2-G complexed with the agonist MK-6892 and in its inactive state, shedding light on how HCA2 activates and signals, which could help in developing new treatments targeting this receptor.
