Publications by authors named "Ryan P O'Quinn"
Article Synopsis
- Chromosome segregation relies on kinetochores forming on centromeric chromatin to interact with spindle microtubules and regulate cell-cycle progression.
- Researchers developed a two-color fluorescence microscopy technique to achieve precise measurements of the spatial arrangement of 16 key proteins involved in kinetochore structure and function.
- The study revealed that a specific change in kinetochore architecture occurs with taxol treatment, highlighting how the KMN network aids in microtubule attachment and suggests an intrakinetochore switch that may help control checkpoint activity during cell division.
Background: Psoriasis is being recognized as an autoimmune disease in which immunocyte-derived cytokines are thought to drive the development of the altered keratinocyte phenotype. Although the role of tumor necrosis factor alpha (TNF-alpha) in psoriasis is not completely understood, it may underlie many of the key steps that lead to induction and maintenance of the disease. Infliximab is an immunoglobulin monoclonal antibody that binds and inactivates TNF-alpha and has been successfully used in the management of TNF-alpha-mediated diseases, such as Crohn disease and rheumatoid arthritis.
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