Systemic antimicrobials as an adjunct in the management of periodontitis - which drug is best?

Design: This study is a systematic review and meta-analysis that assesses systemic antimicrobials: azithromycin (AZT) and amoxicillin/metronidazole (AMX/MTZ), as adjuvants to subgingival instrumentation in the treatment of periodontitis. The aim is to establish if one antimicrobial is superior as an adjuvant therapy in the management of periodontal disease.

Study Selection: This systematic review and meta-analysis included randomised controlled trials (RCTs), controlled clinical trials, and prospective and retrospective human studies.

Multi-nutrients and periodontal disease - a new adjunct to improving treatment outcomes? A randomised placebo-control clinical trial.

Design: This study by Laky et al. is a single-centre, double-blinded randomised placebo-controlled clinical trial, examining the effects of micronutrient supplementation in combination with non-surgical hygiene phase therapy (nsHPT) for Stage III and IV periodontal disease. The study was carried out at the Medical University of Vienna (Austria), School of Dentistry.

Does the use of antimicrobials in different periodontal treatment strategies result in better treatment outcomes? - A radiographic analysis.

Design: The paper by Kubberød et al. is a single-centre, double-blinded, prospective randomised control trial, comparing the radiographic alveolar bone levels in patients with periodontal disease following different treatment protocols over a 5-year period. In total, 184 patient were recruited to the study, and 161 (87.