Publications by authors named "Ryan Margolin"
Male circumcision is a prevalent, straightforward procedure. Cultural, religious, and/or social factors are the main determinants in the decision to undergo circumcision. The method of circumcision and age of the patient at the time of circumcision varies, dependent on the deciding determinant: cultural or religious tradition, personal hygiene, preventive health, or medical need.
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- Low-intensity transcranial focused ultrasound (tFUS) offers a new, non-invasive way to stimulate the brain with high precision and depth, making it important to study its effects on awake animals rather than relying solely on anesthesia, which can skew results.
- Researchers created a small tFUS device that can be attached to rats' skulls, allowing for brain stimulation while the animals are alert and moving freely, which revealed a more robust response in their physical movements compared to when they were anesthetized.
- Overall, this study demonstrates that using awake models for tFUS research could lead to more accurate insights into the effects of brain stimulation, as it reduced variability in responses while maintaining the safety of the animals.
Article Synopsis
- Low-intensity transcranial focused ultrasound (FUS) is a non-invasive technique that can stimulate deep brain areas with high precision.
- Previous studies had focused on the short-term effects of FUS, but this research investigated whether FUS can have lasting effects that last for 30 minutes or more.
- The findings showed that FUS applied to rats led to long-lasting changes in brain activity, suggesting that this method might be capable of inducing neuroplasticity.
This study examined the effects of pulsed focused ultrasound (FUS) in disrupting nerve conduction. FUS operating at a 210 kHz fundamental frequency was administered to the medial and lateral giant axonal nerve fibers of earthworms in a burst of pulses (1 ms tone burst duration, 20 Hz pulse repetition frequency). The magnitude and latencies of the nerve potentials induced by electrical stimulation were measured under three experimental conditions - (I) no sonication, (II) sonication at 600 mW/cm spatial-peak temporal-average intensity (Ispta), and (III) sonication at 200 mW/cm Ispta.
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