Publications by authors named "Ryan M Holcomb"

Article Synopsis
  • - A 38-year-old man experienced a heart attack (ST-elevation myocardial infarction) due to a thrombus (blood clot) in his left main coronary artery after contracting SARS-CoV-2, the virus responsible for COVID-19.
  • - Standard treatments like anticoagulation and fibrinolysis failed, leading to worsening heart failure, after which the patient underwent surgical revascularization and recovered fully.
  • - This case emphasizes the need for better treatment strategies for patients with heart issues linked to SARS-CoV-2, suggesting that early surgical intervention may be crucial in similar cases.
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Article Synopsis
  • Depression is common in patients with coronary artery disease and is linked to worse outcomes after coronary artery bypass graft (CABG) surgery, particularly increasing the risk of non-home discharge (NHD).
  • In a study of 31,309 CABG patients, those with a history of depression had a significantly higher rate of NHD (70% increased odds) and longer hospital stays (24% increased odds) compared to non-depressed patients.
  • The findings emphasize the importance of identifying depression preoperatively to enhance patient care and discharge planning for CABG surgery candidates.
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Background: Unplanned hospital readmissions after surgical operations are considered a marker for suboptimal care during index hospitalizations and are associated with poor patient outcomes and increased healthcare resource utilization. Patients undergoing lower extremity bypass (LEB) operations for severe peripheral arterial disease (PAD) have one of the highest readmission rates, among all the vascular and nonvascular surgical operations. This review is meant to evaluate the impact of pre-existing comorbidities (diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), hypertension (HTN), and coronary artery disease (CAD))-on the 30-day readmission rates among patients who underwent LEB for severe PAD.

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Background: The objective of this randomized clinical trial was to investigate the effects of perfusion modalities on cerebral hemodynamics, vital organ injury, quantified by the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) Score, and clinical outcomes in risk-stratified congenital cardiac surgery patients.

Methods: This randomized clinical trial included 159 consecutive congenital cardiac surgery patients in whom pulsatile (n = 83) or nonpulsatile (n = 76) perfusion was used. Cerebral hemodynamics were assessed using transcranial Doppler ultrasound.

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Background And Aim Of The Study: Congenital heart disease is the most common congenital defect among infants born in the United States. Within the first year of life, 1 in 4 of these infants will need surgery. Only one generation removed from an overall mortality of 14%, many changes have been introduced into the field.

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