Publications by authors named "Ryan Lok Man Ho"
Importance: Previous studies showed that 42% to 50% of patients with locally advanced hepatocellular carcinoma (HCC) achieved complete remission (CR) after combined locoregional therapy (LRT) plus immunotherapy (IO). However, data on predictors of CR and long-term clinical outcomes without surgery and after discontinuation of IO are lacking.
Objective: To assess the long-term clinical outcomes among patients with unresectable HCC who achieved CR after LRT-IO and were placed on a watch-and-wait protocol.
Article Synopsis
- The study compares the effectiveness and safety of combining stereotactic body radiotherapy (SBRT) with immunotherapy versus SBRT alone in patients with unresectable hepatocellular carcinoma.
- Results show that the combination therapy (SBRT-IO) led to significantly improved overall survival rates and response compared to SBRT alone, with higher rates of complete and partial responses among patients.
- Despite some cases of severe side effects from immunotherapy, the combination treatment demonstrated better outcomes, suggesting that further research through randomized trials is needed.