Publications by authors named "Ryan L O'Neal"
Upper gastrointestinal neoplasia in the esophagus, stomach, and pancreas is associated with the formation of preneoplastic metaplasias. We have previously reported the up-regulation of human epididymis protein 4 (HE4) in all metaplasias in the stomach of humans and mice. We have now sought to evaluate the expression of HE4 in metaplasias/preneoplastic precursors and cancers of the human stomach, pancreas, and esophagus.
View Article and Find Full Text PDFObjective: Metaplastic lineages in the oxyntic mucosa of the stomach are critical preneoplastic precursors of gastric cancer. Recent studies have demonstrated that spasmolytic polypeptide-expressing metaplasia (SPEM) in the mouse oxyntic mucosa arises from transdifferentiation of mature gastric chief cells. Other investigations of intestinal progenitor cells have shown that cells demonstrating transcriptional activity for leucine-rich repeat containing G-protein-coupled receptor 5 (Lgr5) in the intestine, colon and gastric antrum function as adult stem cells.
View Article and Find Full Text PDFMature chief cells are cryptic progenitors for metaplasia in the stomach.
Gastroenterology
December 2010
Article Synopsis
- Gastric cancer develops in an abnormal stomach lining where parietal cells are lost, and mucous cells undergo changes, with mucous cell metaplasia being a significant precursor for cancer.
- Research shows that SPEM, a type of metaplasia, arises from chief cells, especially when the stomach lining is damaged or inflamed through specific treatments or infections.
- The study confirms that mature chief cells can revert back to a more primitive, proliferative state under inflammatory conditions, suggesting they can contribute to the development of SPEM and potentially gastric cancer.