Publications by authors named "Ryan Khodadadi"
A total of 1,925 isolates were tested for antimicrobial susceptibility at the Mayo Clinic Microbiology laboratory (Rochester, Minnesota) from January 2012 to March 2023, with (35.6%) and (24.4%) identified as the predominant species.
View Article and Find Full Text PDF: is an uncommon pathogen that has been reported to infect musculoskeletal structures. However, studies are largely limited to case reports, and little is known regarding management and outcomes of these infections. : We performed a multicenter retrospective cohort study of adults with culture-confirmed musculoskeletal infections at three Mayo Clinic centers in Arizona, Florida, and Minnesota from November 2011 through April 2022.
View Article and Find Full Text PDFWe examined the effect of preoperative antibiotic exposure and duration on synovial fluid samples from patients with native joint septic arthritis of the hip/knee. While exposure before diagnostic arthrocentesis did not affect fluid parameters, increased duration was associated with a decreased total nucleated cell count, underscoring the complex antibiotic effects on synovial fluid parameters.
View Article and Find Full Text PDFBackground: Nocardia often causes pulmonary infection among those with chronic pulmonary disease or immunocompromising conditions. Trimethoprim-sulfamethoxazole (TMP-SMX) is recommended as first-line treatment, though little data exists regarding outcomes of different dosing regimens.
Methods: We performed a multicenter retrospective cohort study of adult patients with non-disseminated pulmonary nocardiosis initially treated with TMP-SMX monotherapy.
Article Synopsis
- Identifying and treating patients with acute Q fever is important to avoid complications and challenges arise in diagnosis, risk assessment, and treatment plans.
- A study analyzed 31 Mayo Clinic patients with acute Q fever, primarily men with a median age of 58, showing common symptoms like hepatitis and pneumonia, and revealing varied prophylaxis practices.
- The study highlights inconsistencies in treatment approaches due to the absence of clear clinical guidelines, emphasizing the need for randomized trials to create effective management protocols.
Background: A multitude of factors are considered in an infectious disease (ID) training program's meticulous selection process of ID fellows but their correlation to pre and in-fellowship academic success as well as post-fellowship academic success and short-term outcomes is poorly understood. Our goal was to investigate factors associated with subsequent academic success in fellowship as well as post-fellowship short-term outcomes.
Methods: In 2022, we retrospectively analyzed deidentified academic records from 39 graduates of the Mayo Clinic Rochester ID Fellowship Program (1 July 2013- 30 June 2022).
Article Synopsis
- Nocardiosis mainly affects immunocompromised patients and can recur, leading to secondary prophylaxis for those at high risk, yet data on its recurrence and prophylaxis effectiveness is limited.
- A study examined 303 adults diagnosed with nocardiosis from Nov 2011 to Apr 2022, focusing on those who completed primary treatment and had follow-up, using propensity score matching to analyze secondary prophylaxis effects.
- Results showed a low recurrence rate (5%) with recurrences mostly occurring shortly after treatment or years later, but secondary prophylaxis did not significantly reduce recurrence risk, suggesting that long-term antibiotics may not be necessary for everyone.
Background: Native joint septic arthritis (NJSA) is definitively diagnosed by a positive Gram stain or culture, along with supportive clinical findings. Preoperative antibiotics are known to alter synovial fluid cell count, Gram stain, and culture results and are typically postponed until after arthrocentesis to optimize diagnostic accuracy. However, data on the impact of preoperative antibiotics on operative culture yield for NJSA diagnosis are limited.
View Article and Find Full Text PDFArticle Synopsis
- - Majocchi's granuloma (MG) is a rare fungal infection predominantly affecting hair follicles, often linked to previous use of immunosuppressants and corticosteroids, with case data coming from past reports due to its uncommon nature.
- - A study analyzed 147 adult patients over 30 years, revealing a median patient age of 55.6 years, with most patients being male, and Trichophyton species identified as the primary cause of MG.
- - Treatment typically involved a median duration of 31.5 days, primarily using oral terbinafine, leading to a successful clinical resolution in 96.6% of patients, although accurate diagnosis usually requires histopathologic confirmation.
Article Synopsis
- Nocardiosis primarily affects immunocompromised patients and those with chronic lung diseases, with mixed findings regarding the impact of disseminated infections on outcomes.
- In a study of 511 adults, 31.3% had advanced infections and 15.8% died within a year; advanced infections were linked to higher mortality rates, while disseminated infections were not.
- The research suggests that factors like the Charlson Comorbidity Index and specific infection sites are more important for predicting mortality than the mere presence of disseminated infections, highlighting the need for further studies focusing on these aspects.
Background: A multitude of factors are considered in an infectious diseases (ID) training program's meticulous selection process of ID fellows but their correlation to pre and in-fellowship academic success as well as post-fellowship academic success and short-term outcomes is poorly understood. Our goal was to investigate factors associated with subsequent academic success in fellowship as well as post-fellowship short-term outcomes.
Methods: In 2022, we retrospectively analyzed deidentified academic records from 39 graduates of the Mayo Clinic Rochester ID Fellowship Program (July 1, 2013- June 30, 2022).
Background: Specific pretransplant infections have been associated with poor posttransplant outcomes. However, the impact of pretransplant Nocardia isolation has not been studied.
Methods: We performed a retrospective study from three centers in Arizona, Florida, and Minnesota of patients with Nocardia infection or colonization who subsequently underwent solid organ or hematopoietic stem cell transplantation from November 2011 through April 2022.
Article Synopsis
- Majocchi's granuloma (MG) is a rare type of skin infection that occurs in hair follicles, usually caused by dermatophytes (a group of fungi).
- The condition is specifically identified as a form of deep fungal folliculitis, which means it affects deeper layers of the skin and hair follicles.
- This report highlights a specific case involving MG that appeared on the face, showcasing the condition's impact on facial skin.
is a fastidious Gram-positive, partially acid-fast, anaerobic, catalase positive bacterium that has been reported to be a rare cause of abdominal, breast, spinal, and liver abscesses. Here, three vascular graft infections (VGIs) and cardiac infections are reported.
View Article and Find Full Text PDFMethicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with poor outcomes. Ceftriaxone offers logistical advantages over other standard therapies, though in vitro studies have questioned its efficacy and clinical studies of ceftriaxone in MSSA bacteremia are conflicting.We performed a multicenter, retrospective cohort study of adult patients who received ceftriaxone, cefazolin, or antistaphylococcal penicillins as definitive therapy for MSSA bacteremia from 2018 to 2019.
View Article and Find Full Text PDFThe diagnosis of Q fever can be challenging and a high index of suspicion is necessary. Within this case series, we highlight the utility of the microbial cell-free DNA next-generation sequencing or Karius Test in the timely diagnosis and management of acute Q fever.
View Article and Find Full Text PDFAntispike monoclonal antibody treatment of 180 B-cell-depleted patients with mild-to-moderate coronavirus disease 2019 (COVID-19) resulted in good outcomes overall, with only 12.2% progressing to severe disease, 9.4% requiring hospitalization, 0.
View Article and Find Full Text PDFArticle Synopsis
- The study looks at a method called PROCT to find out why some people's blood takes longer to clot, using tests like PT and aPTT.
- Researchers reviewed medical records of patients who had these prolonged clotting times from 2010 to 2017.
- Results showed that many patients had conditions causing the problem, with vitamin K deficiency, lupus anticoagulant, and liver disease being common causes.
Objective: Although considerable emphasis is placed on the attainment of honors in core medical school clerkships, little is known about what student characteristics are used by attending physicians to earn this designation. The purpose of this study was to evaluate what values and characteristics that attending physicians consider important in the evaluation of Pediatrics and Internal Medicine clerkship students for clinical honors designation.
Methods: This cross-sectional survey study was framed around Accreditation Council for Graduate Medical Education (ACGME) competencies.
Purpose: To explore faculty perspectives on which characteristics of high-performing clerkship students are most important when determining an honors or top grade designation for clinical performance.
Method: In 2016-2017, the authors surveyed faculty (teaching ward attendings) for internal medicine clerkships and 1 pediatrics clerkship in inpatient settings at 5 U.S.