Publications by authors named "Ryan K Higgins"
Sci Transl Med
October 2021
Article Synopsis
- Researchers discovered a small-molecule degrader, HB007, that targets and degrades the SUMO1 protein in cancer cells, which is pivotal for cancer progression.
- The development of HB007 came from screening a library of drug-like compounds and led to enhanced anticancer effects in lab and animal models.
- HB007 functions by binding to the CAPRIN1 protein, facilitating the recruitment of FBXO42 and SUMO1 to an E3 ubiquitin ligase complex, ultimately leading to the degradation of SUMO1 and suppression of various cancers in mice.
