Publications by authors named "Ryan Joyce"

This paper discusses the use of AutoHotkey (AHK) and programmable peripheral computing devices to enhance the workflow of diagnostic radiologists. Multiple features designed and coded by an emergency teleradiologist to optimize efficiency and complete redundant tasks with ease are presented. The full AutoHotkey script, which currently supports Visage PACS, PowerScribe 360, and Epic EHR, is available in the article appendix.

View Article and Find Full Text PDF

Background: This study updates the American Association for the Surgery of Trauma (AAST) Organ Injury Scale (OIS) for renal trauma using evidence-based criteria for bleeding control intervention.

Methods: This was a secondary analysis of a multicenter retrospective study including patients with high-grade renal trauma from seven level 1 trauma centers from 2013 to 2018. All eligible patients were assigned new renal trauma grades based on revised criteria.

View Article and Find Full Text PDF

The surging demand for diagnostic imaging has highlighted inefficiencies with traditional input devices. Radiologists, using conventional mice and keyboards, grapple with cumbersome shortcuts leading to fatigue, errors, and possible injuries. Gaming keyboards, designed for gamers' precision and adaptability, feature customizable keys that simplify complex tasks into single-touch actions, offering radiologists a more efficient workflow with less physical and mental strain.

View Article and Find Full Text PDF

SARS-CoV-2 main protease (M) is a validated antiviral drug target of nirmatrelvir, the active ingredient in Pfizer's oral drug Paxlovid. Drug-drug interactions limit the use of Paxlovid. In addition, drug-resistant M mutants against nirmatrelvir have been identified from cell culture viral passage and naturally occurring variants.

View Article and Find Full Text PDF

Objective: To study the prevalence and management of shattered kidney and to evaluate if the new description of "loss of identifiable renal anatomy" in the 2018 American Association for the Surgery of Trauma (AAST) organ injury scale (OIS) would improve the ability to predict bleeding control interventions.

Methods: We used high-grade renal trauma data from 21 Level-1 trauma centers from 2013 to 2018. Initial CT scans were reviewed to identify shattered kidneys, defined as a kidney having ≥3 parenchymal fragments displaced by blood or fluid on cross-sectional imaging.

View Article and Find Full Text PDF

Purpose: To investigate management trends for American Association for the Surgery of Trauma (AAST) grade V renal trauma with focus on non-operative management.

Methods: We used prospectively collected data as part of the Multi-institutional Genito-Urinary Trauma Study (MiGUTS). We included patients with grade V renal trauma according to the AAST Injury Scoring Scale 2018 update.

View Article and Find Full Text PDF

The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in orthopoxvirus antivirals. Monkeypox belongs to the genus of the Poxviridae family, which also includes the variola virus, vaccinia virus, and cowpox virus. Two orally bioavailable drugs, tecovirimat and brincidofovir, have been approved for treating smallpox infections.

View Article and Find Full Text PDF

Estrogen contributes to the development of breast cancer through estrogen receptor (ER) signaling and by generating genotoxic metabolites that cause oxidative DNA damage. To protect against oxidative stress, cells activate nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream cytoprotective genes that initiate antioxidant responses and detoxify xenobiotics. Nrf2 activation occurs by inhibiting the protein-protein interaction (PPI) between Nrf2 and its inhibitor Keap1, which otherwise targets Nrf2 for ubiquitination and destruction.

View Article and Find Full Text PDF
Article Synopsis
  • SARS-CoV-2 is the virus responsible for COVID-19, which has caused over 6.5 million deaths since late 2019, highlighting the urgent need for diagnostic tools, vaccines, and antiviral treatments.
  • Currently, three antiviral drugs—remdesivir, molnupiravir, and paxlovid—are approved by the FDA, but their effectiveness and potential drug interactions emphasize the need for more options amid emerging virus variants.
  • The research focuses on developing main protease (M) inhibitors that selectively target the virus, utilizing methods like the FlipGFP assay to assess how effectively these new inhibitors work against different strains.
View Article and Find Full Text PDF

The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an effective counter measure to decrease hospitalization and the mortality rate in many countries. However, with the risk of mutated strains decreasing the efficacy of the vaccine, there has been an increasing demand for antivirals to treat COVID-19. While antivirals, such as remdesivir, have had some success treating COVID-19 patients in hospital settings, there is a need for orally bioavailable, cost-effective antivirals that can be administered in outpatient settings to minimize COVID-19-related hospitalizations and death.

View Article and Find Full Text PDF

Objective: To find clinical or radiographic factors that are associated with angioembolization failure after high-grade renal trauma.

Material And Methods: Patients were selected from the Multi-institutional Genito-Urinary Trauma Study. Included were patients who initially received renal angioembolization after high-grade renal trauma (AAST grades III-V).

View Article and Find Full Text PDF

Background: Renal trauma grading has a limited ability to distinguish patients who will need intervention after high-grade renal trauma (HGRT). A nomogram incorporating both clinical and radiologic factors has been previously developed to predict bleeding control interventions after HGRT. We aimed to externally validate this nomogram using multicenter data from level 1 trauma centers.

View Article and Find Full Text PDF

Magnetic resonance imaging (MRI) is frequently used in the imaging evaluation of wrist pain. The complex anatomy of the wrist can be demonstrated by MRI. Three tesla (3 T) MRI offers increased signal-to-noise ratio relative to 1.

View Article and Find Full Text PDF

Purpose: In 2018 the American Association for the Surgery of Trauma revised renal injury grading. One change was inclusion of segmental kidney infarction under grade IV injuries. We aimed to assess how segmental kidney infarction will change the scope of grade IV injuries and compare bleeding control interventions in those with and without isolated segmental kidney infarction.

View Article and Find Full Text PDF

l-Ascorbate (vitamin C) is ubiquitous in both our diet and the environment. Here we report that H16 ( ATCC 17699) uses l-ascorbate as sole carbon source via a novel catabolic pathway. RNaseq identified eight candidate catabolic genes, sequence similarity networks, and genome neighborhood networks guided predictions for function of the encoded proteins, and the predictions were confirmed by assays and growth phenotypes of gene deletion mutants.

View Article and Find Full Text PDF

Background: Current guidelines from the American College of Obstetricians and Gynecologists recommend antibiotic prophylaxis for cesarean delivery immediately before incision. The purpose of this study was to measure and describe correlates of adherence to these guidelines in a sample of United States anesthesiologists.

Methods: We invited a random sample of the membership of the American Society of Anesthesiologists (n = 10,000) to complete an online survey.

View Article and Find Full Text PDF

Introduction: Common causes of non-traumatic acute cerebral edema include malignant hypertension, hyponatremia, anoxia, and cerebral vascular accident. The computed tomographic images and data obtained during care of the patient described in this case report provide evidence that hypercarbia can cause increased intracranial pressure and coma without permanent brain injury. Partial pressure of carbon dioxide evaluation for coma is essential to provide faster diagnosis and therapeutic correction in certain common critical disease states.

View Article and Find Full Text PDF