Utility of Gene Expression Profiling in Skin Cancer: A Comprehensive Review.

Understanding the metastatic potential of a skin cancer is essential to effective management. Gene expression profiling (GEP) is an innovative technology that has allowed for a better understanding of tumor biology in various skin cancers. Current methods focus on identifying and quantifying ribonucleic acid (RNA) transcripts in tissue samples.

Trigeminal trophic syndrome in a pediatric patient with diffuse intrinsic pontine glioma.

A 13-year-old girl with a history of diffuse intrinsic pontine glioma (DIPG) suffered from progressively worsening facial ulcerations secondary to paresthesia-induced self-excoriation. She was diagnosed with trigeminal trophic syndrome (TTS) induced by DIPG and struggled to heal her lesions in the background of this excoriation disorder. A multidisciplinary approach that included mood disorder management with sertraline and amitriptyline helped diminish paresthesia, improve her quality of life, and promote healing of the ulcers despite the progression of her DIPG.

Mycobacterium chelonae-abscessus Complex Infection After Flatfoot Reconstruction.

Mycobacterium infections involving tuberculosis in the foot are rare but cases are readily available in published studies. Atypical or nontuberculosis mycobacterium foot infections are rare, especially those involving the soft tissue and bone, and have been infrequently reported. To date, no case reports involving atypical mycobacterium infection after elective foot surgery have been reported.

Synovial Chondromatosis Surrounding the First Metatarsophalangeal Joint: A Case Report.

Unlabelled: Synovial chondromatosis is a benign synovial tumor that rarely occurs in the foot. We present a case of a 36-year-old male who underwent surgical excision of primary synovial chondromatosis of the first metatarsophalangeal joint. This report also presents a review of the literature related to synovial chondromatosis of the foot.

Narrowing the normal range for lateral ankle ligament stability with stress radiography.

Stress radiographs are commonly performed to evaluate lateral ankle ligament stability; however, little agreement exists on the physiologic limits obtained from the anterior drawer and talar tilt stress tests. Published studies have reported the normal range for the anterior drawer test to be 3 to 10 mm and the normal range for the talar tilt test to be 0° to 23° for the uninjured ankle, leading to inconsistent interpretation. The primary objective of the present study was to narrow the threshold for the diagnosis of ankle ligament injury using stress radiographs by refining the values seen in the normal ankle.

Histologic evaluation of intermetatarsal Morton's neuroma.

Background: The present study was conducted in an attempt to obtain consistent similarities among histologic findings of surgically excised neuromas. Secondly, we looked for a correlation between the presence of a neuroma with certain comorbidities.

Methods: A total of 22 specimens with a preoperative diagnosis of Morton's neuroma were sent to the pathology laboratory, and evaluation was performed by a single pathologist.

Average depth of tarsometatarsal joint for trephine arthrodesis.

The trephine arthrodesis technique has been shown to be an effective method for various foot and ankle fusion procedures, with acceptable rates of fusion reported. The tarsometatarsal joints are an excellent example for this procedure because of the joint shape and soft tissue stability. The success of this procedure depends on many factors, but a large consideration is adequate joint resection.