Publications by authors named "Ryan J Ezell"
Article Synopsis
- Histone H2A lysine 119 (H2AK119Ub) is modified by the Polycomb repressive complex 1 and later deubiquitinated by the PR-DUB complex, which prevents unwanted gene silencing.
- Key subunits of the PR-DUB complex, BAP1 and ASXL1, are frequently mutated in various cancers, highlighting their importance in regulating gene expression.
- A cryo-EM structure study reveals how BAP1 and ASXL1 interact with histones and DNA, explaining their specificity for H2AK119Ub and how mutations can lead to cancer-related dysregulation of this process.
Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought responsible for their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show that expression of Dsup in reduces oxidative DNA damage and extends the lifespan of budding yeast exposed to chronic oxidative genotoxicity.
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