Micromechanics of contact-bound cohesive granular materials in confined compression.

The mechanical behavior of granular materials results from interparticle interactions, which are predominantly frictional. With the presence of even very small amounts of cohesion this frictional interparticle behavior significantly changes. In this study, we introduce trace amounts of cohesive binder between the intergranular contacts in a sample of quartz particles and apply one-dimensional (1D) compression loading.

Nebulized caffeine alleviates airway hyperresponsiveness in a murine asthma model.

The clinical definition of "difficult asthma" has expanded recently to include an ever-growing subset of patients with symptoms that cannot be controlled by conventional means, forcing the medical community to develop innovative therapeutics. Beneficial effects of coffee for subjects with asthma, primarily the effect of methylxanthine components, have long been described. Methylxanthines, including theophylline and caffeine, inhibit phosphodiesterases and downstream cAMP signaling to prevent mast cell degranulation while promoting immunomodulation (Peleman RA, Kips JC, Pauwels RA.

Adverse outcomes in SARS-CoV-2-infected pregnant mice are gestational age-dependent and resolve with antiviral treatment.

SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical studies assessing therapeutics against SARS-CoV-2 in pregnancy are limited. To address these gaps, we developed a mouse model of SARS-CoV-2 infection during pregnancy.

Assessing continuum plasticity postulates with grain stress and local strain measurements in triaxially compressed sand.

Critical state and continuum plasticity theories have been used in research and engineering practice in soil and rock mechanics for decades. These theories rely on postulated relationships between material stresses and strains. Some classical postulates include coaxiality between stress and strain rates, stress-dilatancy relationships, and kinematic assumptions in shear bands.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment.

SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical studies assessing therapeutics against SARS-CoV-2 in pregnancy are limited. To address these gaps, we developed a mouse model of SARS-CoV-2 infection during pregnancy.

Loss of E-cadherin is causal to pathologic changes in chronic lung disease.

Epithelial cells line the lung mucosal surface and are the first line of defense against toxic exposures to environmental insults, and their integrity is critical to lung health. An early finding in the lung epithelium of patients with chronic obstructive pulmonary disease (COPD) is the loss of a key component of the adherens junction protein called E-cadherin. The cause of this decrease is not known and could be due to luminal insults or structural changes in the small airways.

Force inference in granular materials: Uncertainty analysis and application to three-dimensional experiment design.

Interparticle forces are known to influence mechanical and physical properties of granular materials. A method for inferring forces in two-dimensional and three-dimensional experiments has recently been developed and applied to the problem of examining force statistics, energy dissipation, fracture mechanics, and force-property relations. However, a systematic analysis of uncertainties in the forces inferred through this method has not been undertaken.

Quantifying local rearrangements in three-dimensional granular materials: Rearrangement measures, correlations, and relationship to stresses.

Quantifying the ways in which local particle rearrangements contribute to macroscopic plasticity is one of the fundamental pursuits of granular mechanics and soft matter physics. Here we examine local rearrangements that occur naturally during the deformation of three samples of 3D granular materials subjected to distinct boundary conditions by employing in situ x-ray measurements of particle-resolved structure and stress. We focus on five distinct rearrangement measures, their statistics, interrelationships, contributions to macroscopic deformation, repeatability, and dependence on local structure and stress.

The influence of packing structure and interparticle forces on ultrasound transmission in granular media.

Ultrasound propagation through externally stressed, disordered granular materials was experimentally and numerically investigated. Experiments employed piezoelectric transducers to excite and detect longitudinal ultrasound waves of various frequencies traveling through randomly packed sapphire spheres subjected to uniaxial compression. The experiments featured in situ X-ray tomography and diffraction measurements of contact fabric, particle kinematics, average per-particle stress tensors, and interparticle forces.

Characterization of the crystal structure, kinematics, stresses and rotations in angular granular quartz during compaction.

Three-dimensional X-ray diffraction (3DXRD), a method for quantifying the position, orientation and elastic strain of large ensembles of single crystals, has recently emerged as an important tool for studying the mechanical response of granular materials during compaction. Applications have demonstrated the utility of 3DXRD and X-ray computed tomography (XRCT) for assessing strains, particle stresses and orientations, inter-particle contacts and forces, particle fracture mechanics, and porosity evolution . Although past studies employing 3DXRD and XRCT have elucidated the mechanics of spherical particle packings and angular particle packings with a small number of particles, there has been limited effort to date in studying angular particle packings with a large number of particles and in comparing the mechanics of these packings with those composed of a large number of spherical particles.

Celebrity Influence and Identification: A Test of the Angelina Effect.

Angelina Jolie's announcement that she is a BRCA1 carrier and has had a prophylactic bilateral mastectomy was met with widespread support as well as speculation about its possible impact on the public. These speculations were the subject of a Time magazine cover story titled "The Angelina Effect" (Kluger et al., 2013 ).

The information management processes of women living with HPV.

The human papillomavirus (HPV) represents a significant public health burden because of its widespread prevalence, its links to genital warts and cancers, and the negative psychosocial impact of HPV infection and diagnosis. Scholars have attributed some of these negative effects to insufficient knowledge and information about HPV, prompting research on women's HPV information preferences; however, little is known about how women obtain, avoid, and use this information. To address this lacuna, we designed a study to trace the information management processes of women with HPV.

Public estimates of cancer frequency: cancer incidence perceptions mirror distorted media depictions.

Compared with incidence rates, certain cancers are over- or underrepresented in news coverage. Past content analytic research has consistently documented these news distortions, but no study has examined whether they are related to public perception of cancer incidence. Adults (N = 400) completed a survey with questions about perceived cancer incidence, news consumption, and attention to health news.

Conflicting stories about public scientific controversies: Effects of news convergence and divergence on scientists' credibility.

Surveys suggest that approximately one third of news consumers have encountered conflicting reports of the same information. News coverage of science is especially prone to conflict, but how news consumers perceive this situation is currently unknown. College students (N = 242) participated in a lab experiment where they were exposed to news coverage about one of two scientific controversies in the United States: dioxin in sewage sludge or the reintroduction of gray wolves to populated areas.

Online cancer news: trends regarding article types, specific cancers, and the cancer continuum.

The Internet is one of the fastest growing news sources for many worldwide (Pew Research Center's Project for Excellence in Journalism, 2011), and cancer news is one frequently consumed form of online health information (Google, Inc., 2007). This content analysis of online cancer news (n = 862) retrieved from the four most frequented news websites describes trends regarding specific cancers, stages in the cancer continuum, and types of news articles.

The effects of environment and cyclic fatigue on the mechanical properties of an indirect composite.

Objectives: The purpose of this study was to examine the flexure strength (σ) and fracture toughness (K(IC)) of three indirect dental composites (dentin, body, and incisal) with respect to loading (static and cyclic), testing environments (air and water) and ageing (0 (controls) and 6 months in air and water).

Methods: The specimens were 3 mm × 3 mm × 25 mm bars with the fracture toughness specimens having a 0.75 mm notch machined in the midspan.

Sources of the uncertainty experienced by women with HPV.

Women with genital human papillomavirus (HPV) experience considerable stress and uncertainty as a result of the diagnosis; however, little is known about the sources of uncertainty in HPV. Given that uncertainty creates stress, which might be linked to the pathogenesis of cervical cancer, research on these sources of uncertainty is warranted. To this end, we completed semistructured interviews with 25 women living with HPV, and identified seven sources of uncertainty: The meaning of the diagnosis, the potential for disease progression, finances, the source of the infection, disclosure, sex and reproduction, and the HPV vaccine.

Making sense of cancer news coverage trends: a comparison of three comprehensive content analyses.

Cancer stories (N = 5,327) in the top 50 U.S. newspapers were analyzed by a team of four coders and the results were compared with the earliest analyses of this type (from 1977 and 1980).

Fatigue behaviour of dental composite materials.

Objective: The intent of the project was to evaluate the fatigue behavior of particle and fiber filled dental composites that are fabricated either directly or indirectly using a notched specimen with respect to the number of cycles until failure.

Methods: The materials were five dental composites, three normally cured in the oral cavity (Restolux, Renew and Filtek Supreme), direct processing, and two laboratory produced (BelleGlass, and Tescera), indirect processing. The specimens were 3mmx3mmx25mm bars with a 0.

Characterization of methyl mercury in dental wastewater and correlation with sulfate-reducing bacterial DNA.

Dental wastewater (DWW) was collected over two months from a 12-chair clinic and a single-chair office to identify conditions that may affect Hg methylation. DWW was settled for 24 h and samples were collected from the top and bottom of the supernatant to simulate a range of particles that may escape in-line traps. Total Hg spanned 5 orders of magnitude (0.

Flexure strength evaluation of a laboratory-processed fiber-reinforced composite resin.

Statement Of Problem: A fiber-reinforced composite resin system has been introduced for posterior restorations; however, little information is known regarding possible degradation of its flexure strength with respect to aging and cyclic loading.

Purpose: The aim of this in vitro study was to determine whether the fiber reinforcement improved the flexure strength of an indirect composite resin aged in air and water for 3 months and then subjected to static and cyclic loading.

Material And Methods: The materials tested in this study, non-fiber-reinforced composite resin (n=160) (Tescera Dentin) and fiber-reinforced composite resin (n=160) (Tescera U-beam and Rod), were fabricated as bars, 25.

Assessing text representations with recognition: The interaction of domain knowledge and text coherence.

Readers construct at least 2 interrelated mental representations when they comprehend a text: a textbase and a situation model. Two experiments were conducted with recognition memory to examine how domain knowledge and text coherence influence readers' textbase and situation-model representations. In Experiment 1, participants made remember-know judgments to text ideas.